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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
hyperactivation
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "hyperactivation" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-N2255
CAS No.: 25127-29-1
3
3 Cited Publications
Cat. No.: HY-N8518
CAS No.: 63335-25-1
Category:
Metabolic Disease Phenols Polyphenols Plants Myristica fragrans Houtt. Disease Research Fields Myristicaceae Extract
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M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .
Cat. No.: HY-162565
CAS No.: 3086536-23-1
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CDD-2807 is a blood-testis barrier-penetrant STK33 inhibitor (Kd = 0.02 nM). CDD-2807 acts by impairing sperm motility and hyperactivation, while inhibiting off-target kinases such as CLK4 (Kd = 0.9 nM), CLK2 (Ki = 1.3 nM), RET (Ki = 0.3 nM), and CLK1 (Ki = 3.1 nM). CDD-2807 can be used in research on reversible male contraception .
Cat. No.: HY-119121
CAS No.: 951135-00-5
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JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain .
Cat. No.: HY-W744699
CAS No.: 1438-66-0
Synonyms: (+)-Larixol
Cat. No.: HY-178284
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Factor B-IN-7 (Compound (I)) is a selective Factor B inhibitor. Factor B-IN-7 inhibits Factor B-C3b interaction to suppress complement hyperactivation. Factor B-IN-7 is promising for research of paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy, and age-related macular degeneration (AMD) associated with complement-mediated diseases .
Cat. No.: HY-N8518R
CAS No.: 63335-25-1
Cat. No.: HY-P992321
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Cat. No.: HY-182246
CAS No.: 1301757-19-6
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MC2050 is a selective PARP-1 inhibitor with an IC50 of 119 nM. MC2050 functionally inhibits PARP-1 activity, including hyperactivation induced by oxidative stress, and reduces the poly (ADP-ribosyl) ation level of histone H1. MC2050 protects neuroblastoma cells from oxidative stress-mediated cell death induced by hydrogen peroxide. MC2050 is applicable to research related to neuroblastoma and Burkitt lymphoma .
Cat. No.: HY-185978
CAS No.: 2133456-91-2
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GL-II-73 is a selective, orally active and blood-brain barrier permeable positive allosteric modulator of α5GABAA receptor, acting on the benzodiazepine-binding site of GABAA receptors. The binding selectivity of GL-II-73 for the α5 subtype is 6-, 11- and 12.5-fold higher than that for the α2, α1 and α3 subtypes, respectively . GL-II-73 reverses pilocarpine-induced hyperactivation of dopamine neurons in the ventral tegmental area, improves working memory and pyramidal neuron dendritic morphology in 5xFAD mice, but does not reduce β-amyloid load . GL-II-73 can be used in research related to Alzheimer's disease and temporal lobe epilepsy with comorbid psychosis .
Cat. No.: HY-210438
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L013 is an orally active and selective NRF2 PROTAC degrader. L013 directly binds to the NRF2 protein and promotes NRF2 ubiquitination and UPS-related degradation through a Cullin-dependent, CRBN-related process. L013 inhibits RNA polymerase II transcriptional elongation and downregulates NFE2L2 transcript levels. L013 selectively reduces NRF2 protein/mRNA and inhibits proliferation/colony formation in esophageal squamous cell carcinoma cells with NRF2 hyperactivation. L013 inhibits tumor growth in the KYSE150 esophageal squamous cell carcinoma xenograft mouse model and reduces intratumoral NRF2 and Ki-67 protein levels. L013 can be used for research on esophageal squamous cell carcinoma and lung squamous cell carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
