17

Hypoxanthine

17 Publications Verification

Cat. No.: HY-N0091

CAS No.: 68-94-0

Synonyms: Purin-6-ol; Sarcine

Category:

Natural Products Microorganisms Other Diseases Disease markers Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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8

Vidarabine

8 Cited Publications

Cat. No.: HY-B0277

CAS No.: 5536-17-4

Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

Category:

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV

Vidarabine (Ara-A) is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .

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8

Vidarabine monohydrate

8 Cited Publications

Cat. No.: HY-N6666

CAS No.: 24356-66-9

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV

Research Areas:

Infection

Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .

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7

Xanthine oxidase, Microorganism

7 Cited Publications

Cat. No.: HY-P2755

CAS No.: 9002-17-9

Synonyms: XO; XOD

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Endocrinology

Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

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2

Hypoxanthine-15N4

2 Cited Publications

Cat. No.: HY-N0091S7

CAS No.: 77910-30-6

Synonyms: Purin-6-ol-¹⁵N₄; Sarcine-¹⁵N₄

Hypoxanthine- ¹⁵N₄ is the ¹⁵N labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

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1

Xanthine oxidase, bovine milk

1 Cited Publications

Cat. No.: HY-P2755A

CAS No.: 9002-17-9

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Endocrinology

Xanthine oxidase, bovine milk is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

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1

DEANO sodium

1 Cited Publications

Cat. No.: HY-160424

CAS No.: 92382-74-6

Synonyms: Diethylamine NONOate sodium; Diethylamine nitric oxide sodium

Target:

Reactive Oxygen Species (ROS) Xanthine Oxidase

Research Areas:

Others

DEANO sodium is notric oxide donor. DEANO sodium potentiates the abilitv of hypoxanthine/xanthine oxidase to induce lipid peroxidation as well as DNA single- and double-strand breaks .

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1

Hypoxanthine-d2

1 Cited Publications

Cat. No.: HY-N0091S6

CAS No.: 697807-02-6

Hypoxanthine-d₂ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

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1

Hypoxanthine-13C5,15N4

1 Cited Publications

Cat. No.: HY-N0091S

CAS No.: 1987883-25-9

Synonyms: Purin-6-ol-¹³C₅,¹⁵N₄; Sarcine-¹³C₅,¹⁵N₄

Hypoxanthine- ¹³C₅, ¹⁵N4 is a ¹⁵N-labeled and ¹³C-labled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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8-Azahypoxanthine

Cat. No.: HY-W070294

CAS No.: 2683-90-1

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT). 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma .

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Hypoxanthine-d4

Cat. No.: HY-N0091S5

CAS No.: 2483831-32-7

Hypoxanthine-d₄ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

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2′-Deoxy-GDP trisodium

Cat. No.: HY-W013111

CAS No.: 102783-74-4

Synonyms: dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium

Target:

Nucleoside Antimetabolite/Analog Parasite

Research Areas:

Infection

2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC₅₀ of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .

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DMT-dI

Cat. No.: HY-W010744

CAS No.: 93778-57-5

Synonyms: 5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosine

Target:

Phosphoramidites Nucleoside Antimetabolite/Analog

Research Areas:

Cancer

DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine .

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Hypoxanthine (Standard)

Cat. No.: HY-N0091R

CAS No.: 68-94-0

Synonyms: Purin-6-ol (Standard); Sarcine (Standard)

Category:

Natural Products Microorganisms Disease markers Endogenous metabolite Cancer

Target:

Reference Standards Endogenous Metabolite

Hypoxanthine (Standard) is the analytical standard of Hypoxanthine. This product is intended for research and analytical applications. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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Hypoxanthine-13C5

Cat. No.: HY-N0091S2

CAS No.: 2086337-18-8

Synonyms: Purin-6-ol-¹³C₅; Sarcine-¹³C₅

Hypoxanthine- ¹³C₅ is a ¹³C-labeled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

Cat. No.: HY-W141392

CAS No.: 2245842-16-2

Target:

Nucleoside Antimetabolite/Analog Xanthine Oxidase Phosphoramidites

Research Areas:

Cancer

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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6-O-Methylinosine

Cat. No.: HY-152696

CAS No.: 5746-29-2

Target:

Xanthine Oxidase Nucleoside Antimetabolite/Analog

Research Areas:

Others

6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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HGPRT/TBrHGPRT1-IN-1

Cat. No.: HY-158323

CAS No.: 3081803-13-3

Target:

Parasite

Research Areas:

Infection Cancer

HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both K_i=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer .

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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite

Cat. No.: HY-W392836

CAS No.: 128219-85-2

Target:

Nucleoside Antimetabolite/Analog Xanthine Oxidase Phosphoramidites

Research Areas:

Cancer

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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Gibberellin A34

Cat. No.: HY-W587952

CAS No.: 32630-92-5

Category:

Convolvulaceae Extract Ketones, Aldehydes, Acids Plants 500 - Internal Server Error | MedChemExpress

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