85

2-Aminoethyl diphenylborinate

85 Publications Verification

Cat. No.: HY-W009724

CAS No.: 524-95-8

Synonyms: 2-APB

Target:

Calcium Channel TRP Channel CRAC Channel

Research Areas:

Cardiovascular Disease Inflammation/Immunology

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca ²⁺ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .

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18

D-Mannitol

18 Cited Publications

Cat. No.: HY-N0378

CAS No.: 69-65-8

Synonyms: Mannitol; Mannite

Category:

Natural Products Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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11

Xestospongin C

11 Cited Publications

Cat. No.: HY-103312

CAS No.: 88903-69-9

Purity: ≥99.0%

Synonyms: (-)-Xestospongin C

Category:

Alkaloids Piperidine Alkaloids Animals

Target:

Calcium Channel Apoptosis

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

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10

m-3M3FBS

10 Cited Publications

Cat. No.: HY-19619

CAS No.: 200933-14-8

Target:

Phospholipase Apoptosis

Research Areas:

Cancer

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

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9

GSK2850163

9 Cited Publications

Cat. No.: HY-U00459

CAS No.: 2121989-91-9

Synonyms: GSK163

Target:

IRE1

Research Areas:

Cancer

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC₅₀s of 20 and 200 nM, respectively.

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8

3α-Aminocholestane

8 Cited Publications

Cat. No.: HY-19776

CAS No.: 2206-20-4

Target:

Phosphatase

Research Areas:

Cancer

3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC₅₀ of ~2.5 μM.

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7

Betaine

7 Cited Publications

Cat. No.: HY-B0710

CAS No.: 107-43-7

Synonyms: Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium

Category:

Natural Products Microorganisms Animals Disease markers Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite

Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns ^[1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity .

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6

i-Inositol

6 Cited Publications

Cat. No.: HY-B1411

CAS No.: 87-89-8

Synonyms: myo-inositol; meso-inositol

Category:

Natural Products Anti-aging Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Other Diseases Disease markers Disease Research Fields

Target:

Endogenous Metabolite

i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role .

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6

Calhex 231 hydrochloride

6 Cited Publications

Cat. No.: HY-103320A

CAS No.: 2387505-78-2

Purity: 99.81%

Target:

CaSR

Research Areas:

Metabolic Disease

Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

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5

Kinase, Natto fermentation

5 Cited Publications

Cat. No.: HY-P2373

CAS No.: 133876-92-3

Target:

PAI-1

Research Areas:

Cardiovascular Disease

Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases .

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5

Xylose

5 Cited Publications

Cat. No.: HY-N0537

CAS No.: 58-86-6

Synonyms: D-(+)-Xylose; (+)-Xylose; Wood sugar

Category:

Other Diseases Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:

Environmental Pollutants Endogenous Metabolite

Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .

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5

3-Nitrocoumarin

5 Cited Publications

Cat. No.: HY-111919

CAS No.: 28448-04-6

Purity: 100.0%

Target:

Phospholipase Fungal

Research Areas:

Infection

3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP₃), thereby affecting the calcium signaling pathway .

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5

Aureobasidin A

5 Cited Publications

Cat. No.: HY-P1975

CAS No.: 127785-64-2

Synonyms: Basifungin

Category:

Infection Microorganisms Antifungal Antibiotics Disease Research Disease Research Fields Inflammation/Immunology Other Antibiotics

Target:

Antibiotic Fungal Parasite

Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity .

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