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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
intraperitoneally
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "intraperitoneally" in MCE Product Catalog:
4
Research Areas:
MS-444 (BE-34776) is a HuR (ELAVL1) inhibitor that blocks the cytoplasmic translocation of HuR and inhibits its dimerization. MS-444 reduces cytoplasmic HuR levels by preventing the binding of HuR to ARE-mRNA, without altering the total expression of HuR. MS-444 induces apoptosis, inhibits cell growth, angiogenesis and invasion, and also regulates immune function and microbiota. MS-444 effectively alters the number, size and invasiveness of tumors in various cancer models. MS-444 is tolerable to intraperitoneal injection in vivo and can be applied to research related to colorectal cancer, familial adenomatous polyposis, colitis-associated cancer and glioblastoma .
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2 Cited Publications
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6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .
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2 Cited Publications
Cat. No.: HY-N2542
CAS No.: 115810-13-4
Category:
Triterpenes Terpenoids Cucurbitaceae Extract Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Inflammation/Immunology
Target:
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L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma .
In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice .
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .
Cat. No.: HY-W020012
CAS No.: 78949-95-8
Synonyms: 22-NBD Cholesterol
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Fluoresterol (22-NBD Cholesterol) is a cholesterol-specific fluorescent probe with cholesterol-mimicking binding properties. Fluoresterol is ineffective orally and does not cross the blood-brain barrier. Fluoresterol specifically binds to cholesterol transport-related proteins (such as ABCA1 and ABCG1) and is primarily used in cholesterol metabolism research, particularly for the visualization and quantitative analysis of cholesterol absorption, efflux, intracellular transport efficiency, and reverse cholesterol transport (RCT) processes. The commonly used concentration of Fluoresterol in in vitro experiments is 0.1-10 μM, and the commonly used dose in in vivo experiments is 5-20 mg/kg (gavage or intraperitoneal injection), with excitation/emission wavelengths of 472/540 nm. Fluoresterol can be applied to the study of cholesterol metabolism mechanisms related to hyperlipidemia, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD) .
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MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
Cat. No.: HY-P99925
CAS No.: 1192578-27-0
Synonyms: REGN421
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
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LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration .
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DEPMPO is a phosphorus-substituted nitrone spin trap probe that can capture superoxide anions and hydroxyl radicals. DEPMPO forms stable spin adducts with hydroxyl, aryl, sulfite and superoxide radicals, and the formation of these adducts can be inhibited by catalase or superoxide dismutase. DEPMPO is rapidly absorbed after intraperitoneal injection and distributes uniformly in the liver, heart and blood of mice. DEPMPO can be used in studies related to oxygen radical detection .
Cat. No.: HY-N1884
CAS No.: 29424-96-2
Synonyms: (-)-Naringenin 4',7-dimethyl Ether; (-)-NRG-DM
Category:
Flavonoids Monophenols Zingiberaceae Extract Flavonones Other Diseases Phenols Alpinia officinarum Hance Plants Disease Research Fields
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MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 μM, T1/2=58 minutes; no acute toxicity observed) .
Cat. No.: HY-W276164
CAS No.: 1120-04-3
Synonyms: Sodium stearyl sulfate
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Azacosterol (20.25-Diazacholesterol), also known as Diazasterol, acts as a DHCR24 inhibitor and initiates a cascade of reactions in cortical neurons after being administered orally or via intraperitoneal injection.
Cat. No.: HY-177406
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VR11 aptamer is a DNA-based TNF-α inhibitor with a KD of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research .
Cat. No.: HY-W012663
CAS No.: 106-69-4
Research Areas:
1,2,6-Hexanetriol, a polyol, is an intermediate for wetting agents, solvents, and pharmaceuticals with excellent moisturizing property. 1,2,6-Hexanetriol is a humectant and plasticizer for hydrophilic films. 1,2,6-Hexanetriol has no significant toxicity in rats, rabbits, and dogs via oral (16 mL/kg), intraperitoneal (10 g/kg) and intravenous (5.6 mL/kg) routes. 1,2,6-Hexanetriol can be used for the cosmetics and resin industries .
Cat. No.: HY-W007223
CAS No.: 4350-07-6
Synonyms: D-5-HTP; 5-Hydroxy-D-tryptophan
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Cat. No.: HY-N14880
CAS No.: 31323-50-9
Category:
Target:
Cat. No.: HY-125721
CAS No.: 33956-61-5
Category:
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Cat. No.: HY-159798
NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799); Black: linker (HY-159800); Blue: VHL E3 ligase ligand (HY-112078)) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
