10

AY 9944

10 Publications Verification

Cat. No.: HY-107420

CAS No.: 366-93-8

Purity: 99.67%

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease

AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC₅₀ of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .

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6

PACMA 31

6 Cited Publications

Cat. No.: HY-100433

CAS No.: 1401089-31-3

Purity: 99.32%

Target:

PDI

Research Areas:

Cancer

PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC₅₀ of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues . PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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5

MLS0315771

5 Cited Publications

Cat. No.: HY-112945

CAS No.: 727664-91-7

Purity: 99.46%

Target:

Phosphomannose Isomerase (PMI)

Research Areas:

Metabolic Disease

MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC₅₀ ~1 μM and a K_i of 1.4 μM.

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5

LOC14

5 Cited Publications

Cat. No.: HY-100432

CAS No.: 877963-94-5

Purity: ≥98.0%

Target:

PDI

Research Areas:

Neurological Disease Inflammation/Immunology

LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

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5

Xylose

5 Cited Publications

Cat. No.: HY-N0537

CAS No.: 58-86-6

Synonyms: D-(+)-Xylose; (+)-Xylose; Wood sugar

Category:

Other Diseases Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:

Environmental Pollutants Endogenous Metabolite

Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .

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4

D-Glucose 6-phosphate

4 Cited Publications

Cat. No.: HY-112537

CAS No.: 56-73-5

Purity: 99.90%

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite mTOR

D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

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3

Bacitracin

3 Cited Publications

Cat. No.: HY-107193

CAS No.: 1405-87-4

Category:

Anti-aging Anti-parasitic Disease Research Antibacterial Other Antibiotics Infection Microorganisms Plant Cell Culture Antibiotics Resistance Selection Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Bacterial PDI

Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor .

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3

Sulfopin

3 Cited Publications

Cat. No.: HY-139361

CAS No.: 2451481-08-4

Purity: 99.82%

Synonyms: PIN1-3

Target:

PIN1

Research Areas:

Cancer

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent K_i of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors .

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3

D-Glucose 6-phosphate sodium

3 Cited Publications

Cat. No.: HY-112537B

CAS No.: 54010-71-8

Purity: ≥98.0%

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite mTOR

D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .

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2

KPT-6566

2 Cited Publications

Cat. No.: HY-123847

CAS No.: 881487-77-0

Purity: ≥98.0%

Target:

PIN1

Research Areas:

Cancer

KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC₅₀ value of 640 nM and a K_i value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer .

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2

E64FC26

2 Cited Publications

Cat. No.: HY-122895

CAS No.: 2285446-62-8

Purity: 98.10%

Target:

Apoptosis PDI

Research Areas:

Cancer

E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .

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2

2-Deoxy-D-glucose 6-phosphate disodium

2 Cited Publications

Cat. No.: HY-139409A

CAS No.: 33068-19-8

Purity: ≥98.0%

Target:

Hexokinase Glucose-6-Phosphate Isomerase (GPI)

Research Areas:

Cancer

2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

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1

D-Erythrose 4-phosphate sodium

1 Cited Publications

Cat. No.: HY-N7386A

CAS No.: 103302-15-4

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

D-Erythrose 4-phosphate sodium is a phosphate sodium of the simple sugar Erythrose. Erythritol is actually converted into D-Erythrose 4-phosphate that involves three isomerases .

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1

D-Glyceraldehyde 3-phosphate

1 Cited Publications

Cat. No.: HY-151223

CAS No.: 591-57-1

Purity: 99.84%

Synonyms: Triose phosphate

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Fructose-1,6-bisphosphate aldolase Endogenous Metabolite

D-Glyceraldehyde 3-phosphate (Triose phosphate) is a key intermediate in glycolysis and gluconeogenesis, as well as a carbohydrate product of the Calvin cycle. D-Glyceraldehyde 3-phosphate participates in the biosynthesis of tryptophan and thiamine. D-Glyceraldehyde 3-phosphate is released as an aldehyde under the action of aldolase or triosephosphate isomerase. D-Glyceraldehyde 3-phosphate forms adducts with thiols .

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1

CCF642

1 Cited Publications

Cat. No.: HY-100430

CAS No.: 346640-08-2

Purity: ≥98.0%

Target:

Apoptosis PDI

Research Areas:

Cancer

CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

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1

3-Methyltoxoflavin

1 Cited Publications

Cat. No.: HY-111117

CAS No.: 32502-62-8

Purity: 99.65%

Target:

PDI

Research Areas:

Cancer

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC₅₀ of 170 nM.

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1

PIN1 inhibitor API-1

1 Cited Publications

Cat. No.: HY-116716

CAS No.: 680622-70-2

Purity: 98.54%

Target:

MicroRNA

Research Areas:

Cancer

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC₅₀ of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .

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