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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
isoniazid
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "isoniazid" in MCE Product Catalog:
15
15 Cited Publications
Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
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Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
Synonyms: CC-11050
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Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (HY-B0329)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB) .
Cat. No.: HY-B0329S
CAS No.: 774596-24-6
Synonyms: INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4
Synonyms: Paraniazide; Pasiniazide; Isonicotinic acid hydrazide p-aminosalicylate
Pasiniazid is a chemical complex formed by Isoniazid (HY-B0329) and Para-aminosalicylic acid in a 1:1 molar ratio. Pasiniazid is an antibacterial agent. Pasiniazid is rapidly decomposed into isoniazid and para-aminosalicylic acid in the gastrointestinal tract. Isoniazid exerts a bactericidal effect, while para-aminosalicylic acid delays the acetylation process of isoniazid. Pasiniazid has antibacterial activity against Mycobacterium tuberculosis. Pasiniazid can be used in tuberculosis research .
Category:
Alkaloids Aloe africana Other Diseases Pyridine Alkaloids Plants Liliaceae Extract Disease Research Fields
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Synonyms: INH (Standard); Isonicotinic acid hydrazide (Standard); Isonicotinic hydrazide (Standard)
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Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
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Acetylisoniazid is a primary Isoniazid (HY-B0329) metabolite mediated by N-acetyltransferase (NAT). Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
Cat. No.: HY-145525
CAS No.: 173686-75-4
Synonyms: CAR 18:2; C18:2 Carnitine; L-Carnitine linoleoyl ester
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Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of Isoniazid (Item No. 20378) in mice.
Cat. No.: HY-117492
CAS No.: 13410-86-1
Synonyms: Isonicophen
Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis .
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2) .
Cat. No.: HY-W540036
CAS No.: 1544-68-9
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4-Fluorophenyl isothiocyanate is an aryl isothiocyanate reagent and synthetic building block. 4-Fluorophenyl isothiocyanate is used to prepare quinazolinone derivatives, (S)-naproxen-derived 1,2,4-triazoles, isoniazid-derived thiosemicarbazones, isatin-β-thiosemicarbazones, thioureas, thiazolidinones, thiazolines, triazoles, and thiadiazoles. 4-Fluorophenyl isothiocyanate reacts with hydrazine to form a dimer of two thiocyanate groups linked by hydrazine, and the formation of this dimer can be avoided by reacting tert-butyl carbazate with the isothiocyanate .
Cat. No.: HY-161542
Cat. No.: HY-155722
CAS No.: 2954888-39-0
Mtb-IN-5 (compound (-)17j) is an isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity. Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .
Cat. No.: HY-I0736S
CAS No.: 53907-55-4
Cat. No.: HY-157870
CAS No.: 1708947-22-1
Mtb-IN-6 (Compound C10) is a Mycobacterium tuberculosis(Mtb) respiration inhibitor. Mtb-IN-6 can enhance the bactericidal activity of isoniazid (INH, HY-B0329). Mtb-IN-6 inhibits WT Mtb with an IC50 of 25 µM .
Cat. No.: HY-155720
CAS No.: 2306039-13-2
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant .
Cat. No.: HY-158380
CAS No.: 3125917-86-1
UH-NIP-16 exhibits antimicrobial activity against Mycobacterium tuberculosis, with MIC50 of 1.86 and 3.05 μM, for pathogenic mycobacterial strains H37Rv and CDC1551. UH-NIP-16 synergizes with Streptomycin (HY-B1906), Isoniazid (HY-B0329), Ethambutol (HY-B0535) and Bedaquiline (HY-14881), potentiates their anti-tuberculosis activities .
Cat. No.: HY-175016
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NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
