4609 Results for "

isotropic specificity

" in MedChemExpress (MCE) Product Catalog:

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1510

Rapamycin

1510 Publications Verification

Cat. No.: HY-10219

CAS No.: 53123-88-9

Purity: 99.94%

Synonyms: Sirolimus; AY-22989; NSC 226080

Category:

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Disease Research Disease Research Fields Cancer

Target:

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

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952

Bafilomycin A1

952 Cited Publications

Cat. No.: HY-100558

CAS No.: 88899-55-2

Purity: 99.95%

Synonyms: BafA1

Category:

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields

Target:

Proton Pump Autophagy Antibiotic Bacterial Apoptosis

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

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646

Lipopolysaccharides, from E. coli O55:B5

646 Cited Publications

Cat. No.: HY-D1056

Synonyms: LPS, from Escherichia coli (O55:B5)

Category:

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:

Toll-like Receptor (TLR)

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

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530

BAY 11-7082

530 Cited Publications

Cat. No.: HY-13453

CAS No.: 19542-67-7

Purity: 99.98%

Synonyms: BAY 11-7821

Target:

IKK Deubiquitinase Autophagy Apoptosis NF-κB

Research Areas:

Inflammation/Immunology Cancer

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

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352

SC79

352 Cited Publications

Cat. No.: HY-18749

CAS No.: 305834-79-1

Target:

Akt

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .

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321

(+)-JQ-1

321 Cited Publications

Cat. No.: HY-13030

CAS No.: 1268524-70-4

Purity: 99.90%

Synonyms: JQ1

Target:

Epigenetic Reader Domain Autophagy Ligands for Target Protein for PROTAC SWI/SNF Complex

Research Areas:

Neurological Disease Cancer

(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC₅₀s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)) . (+)-JQ-1 also activates autophagy .

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270

Anti-Flag Magnetic Beads

270 Cited Publications

Cat. No.: HY-K0207

MCE Anti-Flag Magnetic Beads are used for immunoprecipitation (IP) of specific Flag-tagged (DYKDDDDK) proteins expressed in bacterial and mammalian cells and in vitro expression systems, and also suitable for Co-immunoprecipitation and purification of Flag-tagged protein. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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204

Trichostatin A

204 Cited Publications

Cat. No.: HY-15144

CAS No.: 58880-19-6

Purity: 99.53%

Synonyms: TSA

Category:

Anti-aging Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC₅₀ value of 1.8 nM for HDAC .

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181

Anti-HA Magnetic Beads

181 Cited Publications

Cat. No.: HY-K0201

MCE Anti-HA Magnetic Beads are used for immunoprecipitation (IP) of specific HA-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.