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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
itraconazole
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "itraconazole" in MCE Product Catalog:
24
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
Synonyms: (2S,4R)-R-63373
Target:
Research Areas:
(2S,4R)-Hydroxy Itraconazole ((2S,4R)-R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
Synonyms: (Rac)-R-63373-d8
(Rac)-Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
Cat. No.: HY-17514S
CAS No.: 1217510-38-7
Synonyms: R51211-d5
Cat. No.: HY-17514S1
CAS No.: 1217512-35-0
Synonyms: R51211-d3
Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
Category:
Cat. No.: HY-17514S2
CAS No.: 1309272-50-1
Synonyms: R51211-d9
Cat. No.: HY-117789
CAS No.: 112560-33-5
Synonyms: keto-ITZ
Target:
Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam .
Cat. No.: HY-117485
CAS No.: 1776931-05-5
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CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis .
Cat. No.: HY-12772R
CAS No.: 112559-91-8
Synonyms: itraconazole metabolite Hydroxy itraconazole (Standard); R-63373 (Standard)
Target:
Research Areas:
(2S,4R)-Hydroxy Itraconazole (Standard) ((2S,4R)-R-63373 (Standard)) is the analytical standard of (2S,4R)-Hydroxy Itraconazole (HY-12772). This product is intended for research and analytical applications. (2S,4R)-Hydroxy Itraconazole ((2S,4R)-R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
Cat. No.: HY-12772A
CAS No.: 207970-87-4
Synonyms: rel-R-63373
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Research Areas:
rel-Hydroxy Itraconazole (rel-R-63373) is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514) .
Cat. No.: HY-12772S1
CAS No.: 1217516-26-1
Synonyms: (rel)-R-63373-d8
Research Areas:
(rel)-Hydroxy Itraconazole-d8 is the deuterium labeled (rel)-Hydroxy Itraconazole[1].
Cat. No.: HY-12772S4
Synonyms: (2S)-R-63373-d8
Synonyms: (2R,4S)-R-63373-d5
Cat. No.: HY-Z8939
CAS No.: 89848-49-7
Synonyms: Isopropyl itraconazole
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Research Areas:
Itraconazole impurity 9 (Isopropyl Itraconazole) is an impurity of Itraconazole.
Cat. No.: HY-Z8940
CAS No.: 252964-65-1
Synonyms: trans-itraconazole
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Research Areas:
Itraconazole impurity 10 (trans-Itraconazole) is an impurity of Itraconazole.
Cat. No.: HY-Z8941
CAS No.: 89848-51-1
Synonyms: Butyl itraconazole
Target:
Research Areas:
Itraconazole impurity 11 (Butyl Itraconazole) is an impurity of Itraconazole.
Cat. No.: HY-Z8937
CAS No.: 854372-77-3
Synonyms: itraconazole impurity B
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Itraconazole impurity 7 (Itraconazole impurity B) is an impurity of Itraconazole.
Cat. No.: HY-Z8938
CAS No.: 74855-91-7
Synonyms: itraconazole impurity C
Target:
Research Areas:
Itraconazole impurity 8 (Itraconazole impurity C) is an impurity of Itraconazole.
Cat. No.: HY-W706891
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
