22

L-Leucyl-L-Leucine methyl ester hydrochloride

22 Publications Verification

Cat. No.: HY-129905

CAS No.: 6491-83-4

Purity: 98.92%

Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis .

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22

L-Leucyl-L-Leucine methyl ester hydrobromide

22 Publications Verification

Cat. No.: HY-129905A

CAS No.: 16689-14-8

Purity: 99.69%

Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrobromide is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrobromide can be used for research related to lysosomal function and apoptosis .

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19

L-Leucine

19 Cited Publications

Cat. No.: HY-N0486

CAS No.: 61-90-5

Synonyms: leucine

Category:

Metabolic Disease Amino acids Endogenous metabolite

Target:

mTOR Endogenous Metabolite

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

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19

6-Diazo-5-oxo-L-nor-Leucine

19 Cited Publications

Cat. No.: HY-108357

CAS No.: 157-03-9

Purity: 99.98%

Synonyms: L-6-Diazo-5-oxonorleucine; DON

Target:

Glutaminase Bacterial Influenza Virus Antibiotic

Research Areas:

Infection Cancer

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .

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12

GNE-3511

12 Cited Publications

Cat. No.: HY-12947

CAS No.: 1496581-76-0

Purity: 99.54%

Target:

MAP3K

Research Areas:

Neurological Disease

GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a K_i of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases .

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10

Mefluleucine

10 Cited Publications

Cat. No.: HY-114384

CAS No.: 2095886-80-7

Purity: ≥98.0%

Synonyms: NV-5138

Target:

mTOR

Research Areas:

Neurological Disease

Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies .

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10

Mefluleucine hydrochloride

10 Cited Publications

Cat. No.: HY-114384B

CAS No.: 2639392-70-2

Purity: ≥98.0%

Synonyms: NV-5138 hydrochloride

Target:

mTOR

Research Areas:

Neurological Disease

Mefluleucine (NV-513) hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine hydrochloride is used for antidepressant studies .

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7

PF-06446846 hydrochloride

7 Cited Publications

Cat. No.: HY-120088A

CAS No.: 1632250-50-0

Purity: 99.44%

Target:

PCSK9

Research Areas:

Cardiovascular Disease

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34 .

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7

PF-06446846

7 Cited Publications

Cat. No.: HY-120088

CAS No.: 1632250-49-7

Target:

PCSK9

Research Areas:

Cardiovascular Disease

PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .

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7

GPNA hydrochloride

7 Cited Publications

Cat. No.: HY-W011391

CAS No.: 67953-08-6

Target:

Apoptosis ASCT

Research Areas:

Cancer

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na ⁺-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na ⁺-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .

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7

Actinonin

7 Cited Publications

Cat. No.: HY-113952

CAS No.: 13434-13-4

Purity: 98.37%

Synonyms: (-)-Actinonin

Category:

Infection Natural Products Microorganisms Marine natural products Disease Research Fields

Target:

Aminopeptidase Bacterial MMP Apoptosis Antibiotic

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

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5

L-Leucine-d3

5 Cited Publications

Cat. No.: HY-N0486S9

CAS No.: 87828-86-2

L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

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