7280 Results for "

long duplex DNA

" in MedChemExpress (MCE) Product Catalog:
Products (7280)

7280 Results for "long duplex DNA" in MCE Product Catalog:

1253
LY294002
LY294002
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1253 Publications Verification
Cat. No.: HY-10108
CAS No.: 154447-36-6
Purity:  99.86%
Target:  

PI3K Casein Kinase DNA-PK Apoptosis Autophagy

Research Areas:  

Infection Cancer

LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC50 of 98 nM . LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator .
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899
Cisplatin
Cisplatin
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899 Cited Publications
Cat. No.: HY-17394
CAS No.: 15663-27-1
Synonyms: cis-Platinum; CDDP; cis-Diaminodichloroplatinum
Target:  

DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase

Research Areas:  

Cancer

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .
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728
Doxorubicin hydrochloride
Doxorubicin hydrochloride
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728 Cited Publications
Cat. No.: HY-15142
CAS No.: 25316-40-9
Purity:  99.90%
Synonyms: Hydroxydaunorubicin hydrochloride; ADR
Category:  

Infection Quinones Microorganisms Anthraquinones Disease Research Fields

Target:  

Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .
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669
ML385
ML385
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669 Cited Publications
Cat. No.: HY-100523
CAS No.: 846557-71-9
Purity:  99.96%
Target:  

Keap1-Nrf2 Ferroptosis Apoptosis mTOR

Research Areas:  

Cardiovascular Disease Cancer

ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .
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307
Gemcitabine hydrochloride
Gemcitabine hydrochloride
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307 Cited Publications
Cat. No.: HY-B0003
CAS No.: 122111-03-9
Synonyms: LY 188011 hydrochloride
Target:  

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis

Research Areas:  

Cancer

Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
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307
Gemcitabine
Gemcitabine
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307 Cited Publications
Cat. No.: HY-17026
CAS No.: 95058-81-4
Synonyms: LY 188011
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis p38 MAPK

Research Areas:  

Infection Inflammation/Immunology Cancer

Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer .
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306
SYBR Green qPCR Master Mix
SYBR Green qPCR Master Mix
0 Images
306 Cited Publications
Cat. No.: HY-K0501

MCE qPCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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245
Oxaliplatin
Oxaliplatin
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245 Cited Publications
Cat. No.: HY-17371
CAS No.: 61825-94-3
Target:  

DNA/RNA Synthesis Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .
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243
Pevonedistat hydrochloride
Pevonedistat hydrochloride
0 Images
243 Cited Publications
Cat. No.: HY-10484
CAS No.: 1160295-21-5
Purity:  98.58%
Synonyms: MLN4924 hydrochloride
Target:  

NEDD8-activating Enzyme Apoptosis

Research Areas:  

Cancer

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .
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243
Pevonedistat
Pevonedistat
0 Images
243 Cited Publications
Cat. No.: HY-70062
CAS No.: 905579-51-3
Synonyms: MLN4924
Target:  

NEDD8-activating Enzyme Apoptosis

Research Areas:  

Cancer

Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .
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230
Remdesivir
Remdesivir
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230 Cited Publications
Cat. No.: HY-104077
CAS No.: 1809249-37-3
Purity:  99.95%
Synonyms: GS-5734
Target:  

DNA/RNA Synthesis SARS-CoV

Research Areas:  

Infection

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .
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226
Bleomycin hydrochloride
Bleomycin hydrochloride
0 Images
226 Cited Publications
Cat. No.: HY-17565A
CAS No.: 67763-87-5
Target:  

DNA/RNA Synthesis Antibiotic

Research Areas:  

Cancer

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic .
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226
Bleomycin sulfate
Bleomycin sulfate
0 Images
226 Cited Publications
Cat. No.: HY-17565
CAS No.: 9041-93-4
Synonyms: Bleomycin sulfate
Category:  

Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:  

DNA/RNA Synthesis Antibiotic

Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic .
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213
Temozolomide
Temozolomide
0 Images
213 Cited Publications
Cat. No.: HY-17364
CAS No.: 85622-93-1
Synonyms: NSC 362856; CCRG 81045; TMZ
Target:  

DNA Alkylator/Crosslinker Autophagy Apoptosis

Research Areas:  

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
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206
Dihydroethidium
Dihydroethidium
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206 Cited Publications
Cat. No.: HY-D0079
CAS No.: 104821-25-2
Synonyms: Hydroethidine; PD-MY 003
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
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198
Etoposide
Etoposide
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198 Cited Publications
Cat. No.: HY-13629
CAS No.: 33419-42-0
Purity:  99.94%
Synonyms: VP-16; VP-16-213
Category:  

Infection Monophenols 500 - Internal Server Error | MedChemExpress

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