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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
mTOR regulatory complex
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "mTOR regulatory complex" in MCE Product Catalog:
Cat. No.: HY-176904
CAS No.: 2559747-12-3
JPS004 is a PROTAC degrader targeting HDAC1, HDAC2 and HDAC3. JPS004 induces extensive transcriptomic changes in human colon cancer cell line HCT116, including downregulation of HDAC complex components and cell cycle regulatory machinery, modulation of the AKT/mTOR signaling pathway, and upregulation of FOXO-mediated apoptosis and autophagy related genes. JPS004 can be used in colon cancer-related research .
Cat. No.: HY-L267
1,226 compounds
Protein synthesis is a fundamental process that converts genetic information into functional proteins and is essential for maintaining cellular growth, proliferation, differentiation, and metabolic homeostasis. Protein synthesis is precisely regulated by a complex network of signaling pathways, including mTOR, PI3K/Akt, MAPK/ERK, and eIF (eukaryotic translation initiation factor)-mediated signaling. These pathways finely control cellular protein synthesis by regulating translation initiation, ribosomal activity, and the expression and phosphorylation status of key translation factors. Dysregulation of protein synthesis is closely associated with the development and progression of various diseases, including cancer, metabolic disorders, neurodegenerative diseases, and immune-related disorders. Therefore, key proteins, kinases, and translation regulators within these pathways are of significant value for research and drug development.
MCE offers 1,226 small-molecule compounds targeting key components of protein synthesis signaling pathways, covering multiple targets involved in protein synthesis and translational regulation, as well as diverse modes of target modulation and functions. By selectively modulating the activity or function of different pathway components, these compounds can be used to investigate protein synthesis and translational regulatory networks, elucidate the roles of specific targets in cellular physiology and disease processes, and support disease mechanism studies, potential drug target validation, candidate drug evaluation, and the exploration of therapeutic strategies.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
