2

NOX-6-18

2 Cited Publications

Cat. No.: HY-157189

CAS No.: 898211-21-7

Purity: 99.72%

Synonyms: GPR132 antagonist 1

Target:

G2A (GPR132)

Research Areas:

Metabolic Disease

NOX-6-18 (GPR132 antagonist 1) is a GPR132 antagonist with an IC₅₀ of 15.17 nM against the human target. NOX-6-18 inhibits GPR132 activation via interaction with non-conserved residues, blocks activities induced by endogenous agonists and 9 (S)-HODE, and exhibits selectivity for other fatty acid-binding GPCRs. NOX-6-18 regulates macrophage reprogramming, alleviates inflammatory responses, downregulates inflammatory markers and signaling pathways, and reduces the degree of hepatic steatosis and hepatic triglyceride levels. NOX-6-18 regulates metabolic homeostasis, reduces weight gain, enhances glucose metabolism, improves glucose tolerance, decreases fasting blood glucose and insulin levels, and partially reverses reductions in energy expenditure and respiratory quotient. NOX-6-18 can be used in the research of type 2 diabetes .

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1

Norbergenin

1 Cited Publications

Cat. No.: HY-N9447

CAS No.: 79595-97-4

Category:

Natural Products Phenols Polyphenols Plants Other Families Extract

Target:

Free Radical Scavengers Tyrosine Hydroxylase Reactive Oxygen Species (ROS) Apoptosis NF-κB p38 MAPK STAT

Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a K_i value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .

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SA91-0178

Cat. No.: HY-178159

CAS No.: 2244341-81-7

Target:

RNA MTase

Research Areas:

Inflammation/Immunology

SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m ⁷G methylation of RNA, reduces SARM1 stability, mitigates NAD ⁺ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases .

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PT109

Cat. No.: HY-167832

CAS No.: 2059104-90-2

Target:

JNK SGK ROCK Tau Protein MMP DNA/RNA Synthesis Pyruvate Kinase NF-κB COX NO Synthase Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

PT109 is an orally active, blood-brain barrier permeable multi-kinase inhibitor. By inhibiting PTBP1, PT109 promotes the switch of pyruvate kinase isoform from PKM2 to PKM1, thereby effectively inhibiting the proliferation and migration of glioblastoma multiforme and inducing its reprogramming into oligodendrocytes. PT109 also targets and regulates key signaling molecules such as JNK, SGK1, GSK3β to exert neuroprotective effects including promoting neurogenesis, inducing synapse formation and alleviating neuroinflammation. In Alzheimer's disease models, PT109 exhibits significant efficacy in improving spatial learning ability, along with excellent in vivo pharmacokinetic properties. PT109 can be used to investigate metabolic reprogramming of glioblastoma multiforme and neuroprotective mechanisms of Alzheimer's disease .

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LCC-12 formate

Cat. No.: HY-W722277A

Target:

NADH Dehydrogenase SARS-CoV

Research Areas:

Infection Inflammation/Immunology

LCC-12 formate is a mitochondria-targeted Copper ²⁺-selective binder and metabolic/epigenetic reprogramming agent. LCC-12 formate inhibits NAD (H) redox cycling and reduces the NAD (H) pool. LCC-12 formate downregulates the expression of inflammatory genes and improves outcomes in mouse models of bacterial sepsis, endotoxemia, and SARS-CoV-2 infection. LCC-12 formate can be used in research related to acute inflammation, endotoxemia, sepsis, and SARS-CoV-2 infection .

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Acetylvaline

Cat. No.: HY-W015466

CAS No.: 96-81-1

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Amino Acid Derivatives

Acetylvaline is a class of amino acid derivative metabolites. The expression abundance of Acetylvaline is upregulated under heat stress conditions; it participates in the regulation of amino acid biosynthesis, cysteine and methionine metabolic pathways, and mediates the physiological processes of antioxidant defense and energy metabolism reprogramming in Magallana sikamea. Acetylvaline can be released from acetylvalyl-RNA of Turnip Yellow Mosaic Virus (TYMV) by N‑acylaminoacyl‑tRNA hydrolase. Acetylvaline can be used in metabolism-related research .

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TE-11

Cat. No.: HY-173624

CAS No.: 160488-11-9

Target:

Macrophage migration inhibitory factor (MIF)

Research Areas:

Inflammation/Immunology

TE-11 is a MIF tautomerase inhibitor with an IC₅₀ of 5.63 μM. TE-11 ameliorates CD-like colitis, reduces MIF-induced eosinophil and neutrophil migration, and prevents M1 polarization and associated metabolic reprogramming .

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DG1

Cat. No.: HY-149352

Target:

Thymidylate Synthase

Research Areas:

Cancer

DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model .

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Acetylvaline-15N

Cat. No.: HY-W015466S

CAS No.: 355808-21-8

Target:

Isotope-Labeled Compounds Endogenous Metabolite Amino Acid Derivatives

Research Areas:

Metabolic Disease

Acetylvaline- ¹⁵N is the ¹⁵N-labeled Acetylvaline (HY-W015466). Acetylvaline is a class of amino acid derivative metabolites. The expression abundance of Acetylvaline is upregulated under heat stress conditions; it participates in the regulation of amino acid biosynthesis, cysteine and methionine metabolic pathways, and mediates the physiological processes of antioxidant defense and energy metabolism reprogramming in Magallana sikamea. Acetylvaline can be released from acetylvalyl-RNA of Turnip Yellow Mosaic Virus (TYMV) by N‑acylaminoacyl‑tRNA hydrolase. Acetylvaline can be used in metabolism-related research .

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Acetylvaline-13C2

Cat. No.: HY-W015466S1

Target:

Isotope-Labeled Compounds Endogenous Metabolite Amino Acid Derivatives

Research Areas:

Metabolic Disease

Acetylvaline- ¹³C₂ is the ¹³C-labeled Acetylvaline (HY-W015466). Acetylvaline is a class of amino acid derivative metabolites. The expression abundance of Acetylvaline is upregulated under heat stress conditions; it participates in the regulation of amino acid biosynthesis, cysteine and methionine metabolic pathways, and mediates the physiological processes of antioxidant defense and energy metabolism reprogramming in Magallana sikamea. Acetylvaline can be released from acetylvalyl-RNA of Turnip Yellow Mosaic Virus (TYMV) by N‑acylaminoacyl‑tRNA hydrolase. Acetylvaline can be used in metabolism-related research .

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Acetylvaline (Standard)

Cat. No.: HY-W015466R

CAS No.: 96-81-1

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Reference Standards Endogenous Metabolite Amino Acid Derivatives

Acetylvaline (Standard) is the analytical standard of Acetylvaline (HY-W015466). This product is intended for research and analytical applications. Acetylvaline is a class of amino acid derivative metabolites. The expression abundance of Acetylvaline is upregulated under heat stress conditions; it participates in the regulation of amino acid biosynthesis, cysteine and methionine metabolic pathways, and mediates the physiological processes of antioxidant defense and energy metabolism reprogramming in Magallana sikamea. Acetylvaline can be released from acetylvalyl-RNA of Turnip Yellow Mosaic Virus (TYMV) by N‑acylaminoacyl‑tRNA hydrolase. Acetylvaline can be used in metabolism-related research .

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