131

131 Publications Verification

Purity: 99.95%

Synonyms: methyl-beta-cyclodextrin

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

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102

Cholesterol (Water Soluble)

102 Cited Publications

Cat. No.: HY-N0322A

Category:

Lipids Endogenous metabolite

Target:

Liposome

Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)

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96

MPTP

96 Cited Publications

Cat. No.: HY-W114750

CAS No.: 28289-54-5

Target:

Dopamine Receptor Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology

MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a brain penetrant dopamine neurotoxin. MPTP can be used to induce Parkinson’s Disease model. MPTP, a precusor of MPP ⁺, induces apoptosis .

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90

L-NAME hydrochloride

90 Cited Publications

Cat. No.: HY-18729A

CAS No.: 51298-62-5

Synonyms: NG-Nitroarginine methyl ester hydrochloride

Target:

NO Synthase

Research Areas:

Infection Neurological Disease Cancer

L-NAME hydrochloride inhibits NOS with an IC₅₀ of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC₅₀ value of 1.4 μM. L-NAME hydrochloride requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor. L-NAME hydrochloride can be used to induce hypertension and preeclampsia models.

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78

Cy5.5

78 Cited Publications

Cat. No.: HY-D0924

CAS No.: 210892-23-2

Synonyms: Sulfo-Cyanine5.5

Target:

Fluorescent Dye

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cy5.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

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73

Crystal Violet

73 Cited Publications

Cat. No.: HY-B0324A

CAS No.: 548-62-9

Synonyms: Basic Violet 3; Gentian Violet; methyl Violet 10B

Crystal Violet, also known as Gentian violet, methyl violet 10B, is a triphenyl-methane, an alkaline dye that binds to DNA in the nucleus of a cell, staining it a deep purple. It is often used for Gram staining to classify bacteria, or for cell or histological staining[1].

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50

CY5

50 Cited Publications

Cat. No.: HY-D0821

CAS No.: 146368-11-8

Synonyms: Sulfo-Cyanine5

Target:

Fluorescent Dye

Research Areas:

Cancer

CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

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47

CA-074 methyl ester

47 Cited Publications

Cat. No.: HY-100350

CAS No.: 147859-80-1

Purity: 99.62%

Synonyms: CA-074Me

Target:

Cathepsin

Research Areas:

Neurological Disease Cancer

CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.

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46

Rhod-2 AM

46 Cited Publications

Cat. No.: HY-D0989

CAS No.: 145037-81-6

Rhod-2 is a high-affinity visible light excitation wavelength Ca ²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm .

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44

Bardoxolone methyl

44 Cited Publications

Cat. No.: HY-13324

CAS No.: 218600-53-4

Purity: 98.92%

Synonyms: RTA 402; NSC 713200; CDDO methyl ester

Target:

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .

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35

NMDA

35 Cited Publications

Cat. No.: HY-17551

CAS No.: 6384-92-5

Synonyms: N-methyl-D-aspartic acid

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

iGluR Endogenous Metabolite

NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

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28

BODIPY 493/503 methyl bromide

28 Cited Publications

Cat. No.: HY-D1614

CAS No.: 216434-81-0

Target:

Fluorescent Dye

Research Areas:

Others

BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .

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25

S-Adenosyl-L-methionine

25 Cited Publications

Cat. No.: HY-B0617

CAS No.: 29908-03-0

Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Apoptosis

S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

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24

S-Adenosyl-L-methionine disulfate tosylate

24 Cited Publications

Cat. No.: HY-W017770

CAS No.: 97540-22-2

Synonyms: Ademetionine disulfate tosylate; S-Adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Endogenous Metabolite Apoptosis

S-Adenosyl-L-methionine (Ademetionine) disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine disulfate tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine disulfate tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine disulfate tosylate has the potential for, cancer, liver disease and osteoarthritis research .

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23

S-Adenosyl-L-methionine tosylate

23 Cited Publications

Cat. No.: HY-B0617A

CAS No.: 52248-03-0

Synonyms: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Apoptosis

S-Adenosyl-L-methionine (S-Adenosyl methionine) tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine tosylate has the potential for, cancer, liver disease and osteoarthritis research .

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23

CY7

23 Cited Publications

Cat. No.: HY-D0825

CAS No.: 943298-08-6

Synonyms: Sulfo-Cyanine7

Target:

Fluorescent Dye

Research Areas:

Others

CY7 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

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22

L-Leucyl-L-Leucine methyl ester hydrochloride

22 Cited Publications

Cat. No.: HY-129905

CAS No.: 6491-83-4

Purity: 98.92%

Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis .

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22

L-Leucyl-L-Leucine methyl ester hydrobromide

22 Cited Publications

Cat. No.: HY-129905A

CAS No.: 16689-14-8

Purity: 99.69%

Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Caspase

L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrobromide is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrobromide can be used for research related to lysosomal function and apoptosis .

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