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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
myopathy
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "myopathy" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: MVA lithium salt
Target:
1
1 Cited Publications
Synonyms: (±)-Mevalonolactone; Mevalolactone
Category:
Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-P3502
CAS No.: 1841136-73-9
Synonyms: RA101495; RA3193
Target:
Research Areas:
Category:
Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
Category:
Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields
Target:
Target:
Synonyms: REN001; HPP593
Target:
Research Areas:
Mavodelpar (REN001) is a selective PPARδ agonist. Mavodelpar suppresses glomerular injury and renal fibrosis. Mavodelpar can be used for the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD) . Mavodelpar is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: ASP0367; MA-0211
Target:
Research Areas:
Bocidelpar (ASP0367; MA-0211) is a selective, orally active PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD) .
Cat. No.: HY-160821A
CAS No.: 335275-62-2
Synonyms: ManNAc-6P sodium salt
Target:
Research Areas:
N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy .
Cat. No.: HY-132583A
Synonyms: DYM101 sodium
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IONIS-DNM2-2.5Rx sodium is an antisense agent targeting dynamin 2, and has the potential for the research of centronuclear myopathy (CNM) .
Cat. No.: HY-P3502A
Synonyms: RA101495 TFA; RA3193 TFA
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Cat. No.: HY-113071C
CAS No.: 32451-23-3
Synonyms: (S)-MVA
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
(S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .
Cat. No.: HY-132583
CAS No.: 2857839-05-3
Synonyms: DYM101
Target:
Research Areas:
IONIS-DNM2-2.5Rx (DYM101) is an antisense agent targeting dynamin 2. IONIS-DNM2-2.5Rx has the potential for the research of centronuclear myopathy (CNM) .
Cat. No.: HY-107855R
CAS No.: 674-26-0
Synonyms: (±)-Mevalonolactone (Standard); Mevalolactone (Standard)
Category:
Cat. No.: HY-113071AR
CAS No.: 2618458-93-6
Synonyms: MVA lithium salt (Standard)
Cat. No.: HY-168007
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Research Areas:
NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis .
Cat. No.: HY-107855S2
CAS No.: 53771-22-5
Synonyms: (±)-Mevalonolactone-13C; Mevalolactone-13C
Cat. No.: HY-107855S4
CAS No.: 287111-36-8
Synonyms: (±)-Mevalonolactone-13C2; Mevalolactone-13C2
Cat. No.: HY-W752587
CAS No.: 349553-98-6
Synonyms: (±)-Mevalonolactone-d4; Mevalolactone-d4
Cat. No.: HY-L118
200 compounds
Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.
MCE offers a unique collection of 200 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
