29 Results for "

myostatin

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "myostatin" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-112821
CAS No.: 385425-03-6
Purity:  98.22%
Target:  

YAP

Research Areas:  

Inflammation/Immunology

IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model .
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2
2 Cited Publications
Cat. No.: HY-P72632
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Human Rat Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P99388
CAS No.: 1429201-24-0
Synonyms: REGN1033; SAR391786
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Trevogrumab (REGN1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake .
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1
1 Cited Publications
Cat. No.: HY-P99370
CAS No.: 1391726-30-9
Synonyms: LY2495655; Anti-GDF8 / myostatin Reference Antibody (landogrozumab)

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease .
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1
1 Cited Publications
Cat. No.: HY-P99588
CAS No.: 705287-60-1
Synonyms: MYO-029

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .
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Cat. No.: HY-P99518
CAS No.: 1580555-26-5
Synonyms: BMS-986089; RG 6206; RO 7239361; BHV2000
Target:  

TGF-beta/Smad

Research Areas:  

Others

Taldefgrobep alfa (BMS-986089; RG 6206; RO 7239361) is a protein that blocks myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research .
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Cat. No.: HY-132611
CAS No.: 1422959-91-8
Purity:  91.89%
Synonyms: SRP-4053
Research Areas:  

Neurological Disease

Golodirsen (SRP-4053) is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen can restore the expression of the anti-myostatin protein. Golodirsen can be used for the research of duchenne muscular dystrophy (DMD) .
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Cat. No.: HY-P10476
CAS No.: 1621169-52-5
Target:  

TGF-beta/Smad

Research Areas:  

Others

Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a Kd of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders .
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Cat. No.: HY-P990993
CAS No.: 2922218-19-5
Synonyms: GYM-329, RG6237, RG-70240

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Emugrobart (GYM-329, RG6237, RG-70240) is a humanized IgG1κ antibody targeting myostatin (Myostatin; GDF8). Emugrobart binds to pro-myostatin and latent myostatin, blocking their cleavage into mature myostatin; it also has a clearance function, which transports bound myostatin for degradation and allows for cyclic reuse. Emugrobart enhances muscle strength in mouse models of muscle atrophy and increases muscle mass in cynomolgus monkeys. Emugrobart can be used in research on spinal muscular atrophy and facioscapulohumeral muscular dystrophy .
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Cat. No.: HY-P99857
CAS No.: 1629605-31-7
Synonyms: PF-06252616

Target:  

TGF-beta/Smad

Research Areas:  

Metabolic Disease

Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD) .
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Cat. No.: HY-P10242
CAS No.: 1621169-56-9
Target:  

TGF-beta/Smad

Research Areas:  

Others

Myostatin inhibitory peptide 7 is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 inhibits myostatin with a Kd of 29.7 nM. Myostatin inhibitory peptide 7 can be used for researches of muscle atrophic disorders .
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Cat. No.: HY-132611A
Purity:  92.00%
Synonyms: SRP-4053 sodium
Research Areas:  

Neurological Disease

Golodirsen (SRP-4053) sodium is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen sodium restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen sodium can restore the expression of the anti-myostatin protein. Golodirsen sodium can be used for the research of duchenne muscular dystrophy (DMD) .
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Cat. No.: HY-130687A
CAS No.: 23140-52-5
Synonyms: DL-Psicose
Psicose (DL-Psicose) is an orally effective sugar substitute. Psicose activates the PI3K/Akt/mTOR pathway to promote muscle synthesis. Psicose upregulates IGF-1 and downregulates Myostatin. Psicose normalizes mitochondrial dysfunction by increasing G6P activity. Psicose enhances the activity of antioxidant enzymes and reduces oxidative stress markers. Psicose increases muscle mass, grip strength and muscle weight in aged mice and diet-induced obese mice. Psicose improves obesity and type 2 diabetes. Psicose can be used in the research of age-related sarcopenia .
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Cat. No.: HY-P10242A
Target:  

TGF-beta/Smad

Research Areas:  

Others

Myostatin inhibitory peptide 7 TFA is a 23 amino acids peptide, which is derived from amino acids 21 to 43 of the mouse myostatin prodomain. Myostatin inhibitory peptide 7 TFA inhibits myostatin with a Kd of 29.7 nM. Myostatin inhibitory peptide 7 TFA can be used for researches of muscle atrophic disorders .
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Cat. No.: HY-P10476A
Target:  

TGF-beta/Smad

Research Areas:  

Others

Myostatin inhibitory peptide 2 (compd 2) TFA is a myostatin inhibitor with a Kd of 35.9 nM. Myostatin inhibitory peptide 2 TFA can be used for researches of muscle atrophic disorders .
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Cat. No.: HY-P704630
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Human
Source:  
CHO
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Cat. No.: HY-P704631
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Rat Mouse Human
Source:  
CHO
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Cat. No.: HY-P705231
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P705393
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P702874Y
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MSTN; GDF-8; Prev. GDF8; myostatin-B; Growth/Differentiation Factor 8; MSLHP; myostatin; Growth Differentiation Factor 8
Species:  
Rat Human Mouse
Source:  
HEK293
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