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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
myotoxicity
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "myotoxicity" in MCE Product Catalog:
2
Target:
Research Areas:
Atorvastatin lactone is a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity .
Cat. No.: HY-D1005A25
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 5750 (Average)
Cat. No.: HY-120078
CAS No.: 1845753-81-2
Target:
Research Areas:
AZD2716 is an orally active secretory phospholipase A2 (sPLA2) inhibitor. AZD2716 inhibits human GIIA sPLA2 (IC50=10 nM), human GV sPLA2 (IC50=40 nM), human GX sPLA2 (IC50=400 nM), snake venom sPLA2 (IC50=2 pM), and snake (Bothrops jararacussu) Lys49-PLA2-like toxin (Kd=110 μM). AZD2716 inhibits sPLA2 isoforms IIa, V, X, snake venom sPLA2s, and snake venom Lys49-PLA2-like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA2 production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming .
Cat. No.: HY-101873S
Cat. No.: HY-137213
CAS No.: 94061-83-3
Target:
Research Areas:
Fluvastatin lactone is the lactone form of Fluvastatin (HY-14664) detected in human plasma after administration. It competitively or mixed-type inhibits CYP2C9-catalyzed S-Warfarin 7-hydroxylation, and induces myotoxicity in a concentration- and time-dependent manner in rat and primary human skeletal muscle cells, reducing the number of surviving myotubes and causing morphological changes in myotubes. Fluvastatin lactone can be used for studies on myotoxicity and statin-induced myotoxicity .
Cat. No.: HY-101873R
CAS No.: 125995-03-1
Research Areas:
Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone (HY-101873). This product is intended for research and analytical applications. Atorvastatin lactone is a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity .
Cat. No.: HY-16108
CAS No.: 157126-18-6
Target:
Research Areas:
BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle .
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Protocols
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