54

Methyllycaconitine citrate

54 Publications Verification

Cat. No.: HY-N2332A

CAS No.: 351344-10-0

Synonyms: MLA citrate

Target:

nAChR Autophagy Reactive Oxygen Species (ROS) mTOR

Research Areas:

Neurological Disease

Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC₅₀ of 2 nM. Methyllycaconitine citrate inhibits Aβ_25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .

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51

Ivermectin

51 Cited Publications

Cat. No.: HY-15310

CAS No.: 70288-86-7

Purity: 98.28%

Synonyms: MK-933; CD-5024; K-237

Category:

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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35

Acetylcholine chloride

35 Cited Publications

Cat. No.: HY-B0282

CAS No.: 60-31-1

Synonyms: ACh chloride

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

nAChR Calcium Channel Endogenous Metabolite

Acetylcholine (ACh) chloride, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

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35

Acetylcholine iodide

35 Cited Publications

Cat. No.: HY-101086

CAS No.: 2260-50-6

Purity: 98.59%

Synonyms: ACh iodide

Category:

Natural Products Animals

Target:

nAChR Calcium Channel Endogenous Metabolite

Acetylcholine (ACh) iodide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine iodide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine iodide inhibits p53 mutant peptide aggregation in vitro .

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35

Acetylcholine bromide

35 Cited Publications

Cat. No.: HY-B0282A

CAS No.: 66-23-9

Synonyms: ACh bromide

Target:

nAChR Calcium Channel Endogenous Metabolite

Research Areas:

Neurological Disease Cancer

Acetylcholine (ACh) bromide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine bromide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine bromide inhibits p53 mutant peptide aggregation in vitro .

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