37 Results for "

nephritis

" in MedChemExpress (MCE) Product Catalog:
Products (37)

37 Results for "nephritis" in MCE Product Catalog:

2
Vemircopan
Vemircopan
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2 Cited Publications
Cat. No.: HY-139588
CAS No.: 2086178-00-7
Purity:  98.61%
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Target:  

Complement System Interleukin Related

Research Areas:  

Metabolic Disease Inflammation/Immunology

Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
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RO5461111
RO5461111
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1 Cited Publications
Cat. No.: HY-114374
CAS No.: 1252637-46-9
Purity:  98.17%
Target:  

Cathepsin

Research Areas:  

Inflammation/Immunology

RO5461111 a highly specific and orally active antagonist of Cathepsin S with IC50s of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. RO5461111 can effectively inhibit the activation of antigen-specific T cells and B cells. RO5461111 can improve pulmonary inflammation and lupus nephritis .
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Povetacicept
Povetacicept
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Cat. No.: HY-P990706
CAS No.: 2490217-42-8
Synonyms: ALPN-303

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Povetacicept (ALPN-303) is an engineered Fc fusion protein containing the TACI domain, and acts as a dual APRIL/BAFF antagonist. The Kd value of Povetacicept for human BAFF is 59.3 pM, while its Kd value for human APRIL is 1.00 pM. Povetacicept reduces the activation, proliferation, differentiation and survival of B cells, and inhibits the production of immunoglobulins and autoantibodies. Povetacicept can be used in research related to autoimmune hemolytic anemia, immune thrombocytopenia, systemic lupus erythematosus, lupus nephritis and myasthenia gravis .
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Amiselimod hydrochloride
Amiselimod hydrochloride
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Cat. No.: HY-16734A
CAS No.: 942398-84-7
Synonyms: MT-1303 hydrochloride
Target:  

LPL Receptor

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases .
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Sirukumab
Sirukumab
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Cat. No.: HY-P99316
CAS No.: 1194585-53-9
Synonyms: CNTO-136

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis .
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trans-Ned 19
trans-Ned 19
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Cat. No.: HY-103316
CAS No.: 1354235-96-3
Purity:  99.33%
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis .
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Gefurulimab
Gefurulimab
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Cat. No.: HY-P99638
CAS No.: 2456407-94-4
Synonyms: ALXN1720
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Gefurulimab (ALXN-1720) is a high-affinity antibody inhibitor targeting complement protein C5, which can specifically bind to C5 and inhibit its cleavage into C5a and C5b. Gefurulimab can block the activation of the terminal complement pathway and reduce inflammatory damage. Gefurulimab can effectively reduce the formation of membrane attack complex (MAC) and has good pharmacokinetic properties. Gefurulimab can be used to study kidney and autoimmune diseases related to abnormal activation of the complement system, such as IgA nephropathy, lupus nephritis, and myasthenia gravis .
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TLR7/8/9 antagonist 2
TLR7/8/9 antagonist 2
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Cat. No.: HY-153460
CAS No.: 2920729-91-3
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology

TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis .
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RP-220
RP-220
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Cat. No.: HY-P6084
CAS No.: 1541177-35-8
Target:  

NOD-like Receptor (NLR) p38 MAPK Apoptosis

Research Areas:  

Inflammation/Immunology

RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research .
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BI-655064
BI-655064
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Cat. No.: HY-P991513

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA) .
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Anti-Mouse OX40L/CD134L Antibody (RM134L)
Anti-Mouse OX40L/CD134L Antibody (RM134L)
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Cat. No.: HY-P990175

Target:  

Orexin Receptor (OX Receptor)

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse OX40L/CD134L Antibody (RM134L) is an anti-mouse OX40L/CD134L IgG2b monoclonal antibody. Anti-Mouse OX40L/CD134L Antibody (RM134L) reduces immune response by inhibiting the OX40/OX40L signaling pathway. Anti-Mouse OX40L/CD134L Antibody (RM134L) can inhibit plasma cell differentiation and antibody secretion. Anti-Mouse OX40L/CD134L Antibody (RM134L) can prolong the survival time of cell transplantation by inhibiting CD4 + T cells. Anti-Mouse OX40L/CD134L Antibody (RM134L) can be used for researches on inflammation and cancer such as graft versus host disease (GVHD), allergic reaction, lupus nephritis and hepatocellular carcinoma (HCC) .
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Anti-Mouse/Human Integrin β7 Antibody (FIB504)
Anti-Mouse/Human Integrin β7 Antibody (FIB504)
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Cat. No.: HY-P990207
Target:  

Integrin

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma .
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Anti-Mouse ICOS Antibody (7E.17G9)
Anti-Mouse ICOS Antibody (7E.17G9)
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Cat. No.: HY-P990237

Target:  

CD28

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse ICOS Antibody (7E.17G9) is a mouse ICOS agonist IgG2b monoclonal antibody. Anti-Mouse ICOS Antibody (7E.17G9) can upregulate ICOS expression and enhance T cell function. Anti-Mouse ICOS Antibody (7E.17G9) can significantly inhibit the immune regulatory function of dendritic cells (DCs). Anti-Mouse ICOS Antibody (7E.17G9) can eliminate transplant tolerance. Anti-Mouse ICOS Antibody (7E.17G9) can be used for researches on inflammation conditions, cancer and xenotransplantation such as nephritis and pancreatic cancer .
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BIIB023
BIIB023
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Cat. No.: HY-P991439

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

BIIB023 is a human monoclonal antibody (mAb) targeting TNFRSF12A/TWEAKR/CD266. BIIB023 can be used in lupus nephritis and rheumatoid arthritis research .
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Boc-Lys(Z)-OH (DCHA)
Boc-Lys(Z)-OH (DCHA)
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Cat. No.: HY-W109513
CAS No.: 16948-04-2
Target:  

Amino Acid Derivatives

Research Areas:  

Inflammation/Immunology

Boc-Lys(Z)-OH (DCHA) is a involves in synthesis thymosin β4, βg and β6 fragments, and increases E-rosette forming capacity in Lupus Nephritis model. Boc-Lys(Z)-OH (DCHA) involves in synthesis Boc-Lyz-OCH3 and acts as a reagent of peptidyl thrombin inhibitors production .
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JTE 7-31
JTE 7-31
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Cat. No.: HY-122281
CAS No.: 194358-72-0
Target:  

Cannabinoid Receptor

Research Areas:  

Others

JTE 7-31 selectively acts on peripheral cannabinoid receptors, minimizing central nervous system side effects. They exhibit potent immunomodulatory, anti-inflammatory and anti-allergic properties, as well as inhibitory effects on nephritis .
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Triptolidenol
Triptolidenol
0 Images
Cat. No.: HY-N11784
CAS No.: 99694-86-7
Category:  

Celastraceae Extract Terpenoids Diterpenoids Plants 500 - Internal Server Error | MedChemExpress

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