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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
181 Results for "
nephropathies
" in MedChemExpress (MCE) Product Catalog:
Products (181)
181 Results for "nephropathies" in MCE Product Catalog:
54
54 Publications Verification
Cat. No.: HY-W404916
CAS No.: 23795-03-1
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology
Probenecid sodium is an orally active, blood-brain barrier-permeable Pannexin 1 channel inhibitor. Probenecid sodium exhibits anti-inflammatory, antiviral, and neuroprotective activities. Probenecid sodium can be used in research related to multiple sclerosis, focal cerebral ischemic injury, influenza virus infection, and nephropathy .
26
Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
14
Target:
Research Areas:
Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
14
14 Cited Publications
Synonyms: LNP023 hydrochloride
Target:
Research Areas:
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
11
11 Cited Publications
Synonyms: Ononoside; Formononetin 7-O-β-D-glucopyranoside
10
10 Cited Publications
Synonyms: Pimagedine hydrochloride; GER-11; Aminoguanidinium hydrochloride
Target:
Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy .
10
10 Cited Publications
Cat. No.: HY-W020772
CAS No.: 996-19-0
Synonyms: Pimagedine hemisulfate; GER-11 hemisulfate; Aminoguanidinium hemisulfate
Target:
Aminoguanidine (Pimagedine) hemisulfate is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hemisulfate can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hemisulfate has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hemisulfate has antioxidant properties. Aminoguanidine hemisulfate can be used in the research of diabetic nephropathy .
9
9 Cited Publications
Cat. No.: HY-P1430
CAS No.: 592517-80-1
Synonyms: Cell permeable NFAT inhibitor
Research Areas:
9
Research Areas:
8
8 Cited Publications
PF-670462 dihydrochloride is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 dihydrochloride is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 dihydrochloride inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 dihydrochloride blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 dihydrochloride reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 dihydrochloride can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma .
8
8 Cited Publications
Cat. No.: HY-15490A
CAS No.: 950980-98-0
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
PF-670462 is a selective CK1δ and CK1δε inhibitor (Ki of 10 nM and 50 nM, respectively). PF-670462 is also a ZDHHC8-specific inhibitor (Kd 15.9 μM). PF-670462 inhibits CK1-mediated LRRK2 phosphorylation. PF-670462 blocks PER phosphorylation and CK1δ/ε-dependent TGF-β signaling. PF-670462 reduces GPX4 palmitoylation, sensitizing tumor cells to Ferroptosis inducers. PF-670462 can be used for research on Parkinson's disease, NRAS-mutant melanoma, pulmonary fibrosis, chronic lymphocytic leukemia, diabetic nephropathy, and melanoma .
5
Category:
Plant Monophenols Coumarins Phenols Phenylpropanoids Other Families Extract Disease Research Fields Cancer
Target:
5
5 Cited Publications
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity .
5
5 Cited Publications
Cat. No.: HY-W166297
CAS No.: 66778-17-4
Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .
5
5 Cited Publications
Target:
Research Areas:
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity .
3
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Benazepril (CGS14824A) hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor to reduce angiotensin-II production. Benazepril hydrochloride inhibits oxidative stress and inhibits apoptosis by the PI3K/Akt signaling pathway. In addition, Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria. Benazepril hydrochloride can be used in the study of hypertension, heart failure and diabetic nephropathy .
3
3
3 Cited Publications
Research Areas:
Gln-AMS is a potent inhibitor of Aminoacyl-tRNA Synthetase. Gln-AMS blocks the lactylation modification of downstream targets through competitive binding to AARS1, thereby regulating apoptosis, ferroptosis, and the transcriptional processes of related genes. Gln-AMS can be used in research on breast cancer, diabetic nephropathy, and sepsis-associated encephalopathy .
3
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
3
3 Cited Publications
Cat. No.: HY-112861A
Purity: 99.65%
Gln-AMS TFA is a potent inhibitor of Aminoacyl-tRNA Synthetase. Gln-AMS TFA blocks the lactylation modification of downstream targets through competitive binding to AARS1, thereby regulating apoptosis, ferroptosis, and the transcriptional processes of related genes. Gln-AMS TFA can be used in research on breast cancer, diabetic nephropathy, and sepsis-associated encephalopathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
