Target:

Research Areas:

α-Nicotine is the α-isomer of Nicotine. Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist. Nicotine is promising for research of neuropsychiatric disorders (e.g., schizophrenia, ADHD) .

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54

Methyllycaconitine citrate

54 Publications Verification

Cat. No.: HY-N2332A

CAS No.: 351344-10-0

Synonyms: MLA citrate

Target:

nAChR Autophagy Reactive Oxygen Species (ROS) mTOR

Research Areas:

Neurological Disease

Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC₅₀ of 2 nM. Methyllycaconitine citrate inhibits Aβ_25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .

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51

Ivermectin

51 Cited Publications

Cat. No.: HY-15310

CAS No.: 70288-86-7

Purity: 98.28%

Synonyms: MK-933; CD-5024; K-237

Category:

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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35

Acetylcholine chloride

35 Cited Publications

Cat. No.: HY-B0282

CAS No.: 60-31-1

Synonyms: ACh chloride

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

nAChR Calcium Channel Endogenous Metabolite

Acetylcholine (ACh) chloride, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

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35

Acetylcholine iodide

35 Cited Publications

Cat. No.: HY-101086

CAS No.: 2260-50-6

Purity: 98.59%

Synonyms: ACh iodide

Category:

Natural Products Animals

Target:

nAChR Calcium Channel Endogenous Metabolite

Acetylcholine (ACh) iodide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine iodide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine iodide inhibits p53 mutant peptide aggregation in vitro .

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35

Acetylcholine bromide

35 Cited Publications

Cat. No.: HY-B0282A

CAS No.: 66-23-9

Synonyms: ACh bromide

Target:

nAChR Calcium Channel Endogenous Metabolite

Research Areas:

Neurological Disease Cancer

Acetylcholine (ACh) bromide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine bromide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine bromide inhibits p53 mutant peptide aggregation in vitro .

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17

GTS-21 dihydrochloride

17 Cited Publications

Cat. No.: HY-14564A

CAS No.: 156223-05-1

Purity: 99.65%

Synonyms: DMXB-A; DMBX-anabaseine

Target:

nAChR 5-HT Receptor

Research Areas:

Inflammation/Immunology

GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (K_i=20 nM for humanα4β2) and 5-HT3A receptor (IC₅₀=3.1 μM) antagonist .

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16

PNU-282987

16 Cited Publications

Cat. No.: HY-12560A

CAS No.: 123464-89-1

Purity: 99.93%

Target:

nAChR 5-HT Receptor

Research Areas:

Neurological Disease

PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC₅₀ of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT₃ receptor with an IC₅₀ of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems .

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16

Galanthamine hydrobromide

16 Cited Publications

Cat. No.: HY-A0009

CAS No.: 1953-04-4

Synonyms: Galantamine hydrobromide

Category:

Alkaloids Other Alkaloids Amaryllidaceae Extract Plants

Target:

Cholinesterase (ChE) nAChR

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

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13

Niacin hydrochloride

13 Cited Publications

Cat. No.: HY-B0143A

CAS No.: 636-79-3

Synonyms: Nicotinic acid hydrochloride; Vitamin B3 hydrochloride

Category:

Alkaloids Ketones, Aldehydes, Acids Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Apoptosis

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

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11

Kynurenic acid

11 Cited Publications

Cat. No.: HY-100806

CAS No.: 492-27-3

Purity: 99.21%

Synonyms: Quinurenic acid; Fibrostop 2

Category:

Alkaloids Human Gut Microbiota Metabolites Neurological Disease Quinoline Alkaloids Endogenous metabolite Disease Research Fields Endocrinology

Target:

iGluR Endogenous Metabolite Apoptosis CXCR GPR35

Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

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11

Kynurenic acid sodium

11 Cited Publications

Cat. No.: HY-107512

CAS No.: 2439-02-3

Purity: 99.79%

Category:

Alkaloids Quinoline Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

iGluR Apoptosis Endogenous Metabolite CXCR GPR35

Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.

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9

α-Bungarotoxin

9 Cited Publications

Cat. No.: HY-P1264

CAS No.: 11032-79-4

Target:

nAChR

Research Areas:

Neurological Disease

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC₅₀ of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM .

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8

MK-6892

8 Cited Publications

Cat. No.: HY-10680

CAS No.: 917910-45-3

Purity: 98.06%

Target:

GPR109A

Research Areas:

Cancer

MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. K_i and GTPγS EC₅₀ of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively.

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