180

DAPT

180 Publications Verification

Cat. No.: HY-13027

CAS No.: 208255-80-5

Purity: 99.97%

Synonyms: GSI-IX

Target:

Organoid γ-secretase Amyloid-β Autophagy Notch Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC₅₀s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ₄₂, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

138

Alpelisib

138 Cited Publications

Cat. No.: HY-15244

CAS No.: 1217486-61-7

Purity: 99.88%

Synonyms: BYL-719

Target:

PI3K Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

138

Alpelisib hydrochloride

138 Cited Publications

Cat. No.: HY-15244A

CAS No.: 1584128-91-5

Synonyms: BYL-719 hydrochloride

Target:

PI3K Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

Alpelisib (BYL-719) hydrochloride is an orally active PI3Kα-selective inhibitor that blocks the conversion of PIP2 to PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

70

Valproic acid

70 Cited Publications

Cat. No.: HY-10585

CAS No.: 99-66-1

Purity: 99.19%

Synonyms: VPA; 2-Propylpentanoic acid; Dipropylacetic acid

Category:

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

70

Valproic acid sodium

70 Cited Publications

Cat. No.: HY-10585A

CAS No.: 1069-66-5

Purity: 98.14%

Synonyms: Sodium Valproate; VPA sodium; 2-Propylpentanoic acid sodium

Category:

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

29

LY-411575

29 Cited Publications

Cat. No.: HY-50752

CAS No.: 209984-57-6

Target:

Organoid γ-secretase Notch Apoptosis

Research Areas:

Neurological Disease

LY-411575 is a potent γ-secretase inhibitor with IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with an IC₅₀ of 0.39 nM.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

RO4929097

21 Cited Publications

Cat. No.: HY-11102

CAS No.: 847925-91-1

Purity: 99.01%

Target:

γ-secretase Notch

Research Areas:

Neurological Disease Cancer

RO4929097 is an orally active γ secretase inhibitor with an IC₅₀ of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC₅₀ of 14 nM and 5 nM, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

20

Compound E

20 Cited Publications

Cat. No.: HY-14176

CAS No.: 209986-17-4

Purity: 99.97%

Synonyms: γ-Secretase-IN-1

Target:

γ-secretase

Research Areas:

Cancer

Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀s of 0.24, 0.37, 0.32 nM, respectively.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

19

Jagged-1 (188-204)

19 Cited Publications

Cat. No.: HY-P1846

CAS No.: 219127-21-6

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

19

Jagged-1 (188-204) TFA

19 Cited Publications

Cat. No.: HY-P1846A

Target:

Notch

Research Areas:

Cancer

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

18

Nirogacestat

18 Cited Publications

Cat. No.: HY-15185

CAS No.: 1290543-63-3

Purity: 99.78%

Synonyms: PF-3084014

Target:

γ-secretase Apoptosis

Research Areas:

Neurological Disease Cancer

Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC₅₀ of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

18

Nirogacestat dihydrobromide

18 Cited Publications

Cat. No.: HY-15185B

CAS No.: 1962925-29-6

Purity: 99.63%

Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide

Target:

γ-secretase Apoptosis

Research Areas:

Cancer

Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC₅₀ of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

16

Tangeretin

16 Cited Publications

Cat. No.: HY-N0133

CAS No.: 481-53-8

Synonyms: Tangeritin; NSC53909; NSC618905

Category:

Flavonoids Flavones Plants Other Families Extract Disease Research Fields Cancer

Target:

Notch Apoptosis

Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

FLI-06

13 Cited Publications

Cat. No.: HY-15860

CAS No.: 313967-18-9

Purity: 99.88%

Target:

Notch

Research Areas:

Cancer

FLI-06 is an inhibitor of Notch signaling with an EC₅₀ of 2.3 μM.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

12

Limantrafin

12 Cited Publications

Cat. No.: HY-135145

CAS No.: 218457-67-1

Purity: 99.89%

Synonyms: CB-103

Target:

Notch

Research Areas:

Cancer

Limantrafin (CB-103) is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. Limantrafin has anti-tumor activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

12

Semagacestat

12 Cited Publications

Cat. No.: HY-10009

CAS No.: 425386-60-3

Purity: 98.89%

Synonyms: LY450139

Target:

γ-secretase Amyloid-β Notch

Research Areas:

Neurological Disease

Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC₅₀s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC₅₀ of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

12

ISX-9

12 Cited Publications

Cat. No.: HY-12323

CAS No.: 832115-62-5

Purity: 99.19%

Synonyms: Isoxazole 9

Target:

Calcium Channel

Research Areas:

Neurological Disease

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca ²⁺ influx through both voltage-gated Ca ²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Carvacrol

11 Cited Publications

Cat. No.: HY-N0711

CAS No.: 499-75-2

Synonyms: Cymophenol

Category:

Preservatives Monophenols Phenols Plants 500 - Internal Server Error | MedChemExpress

country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Cart

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.

notch

Oops!