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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
nuclear division
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "nuclear division" in MCE Product Catalog:
12
12 Cited Publications
Research Areas:
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .
Cat. No.: HY-120921
CAS No.: 156052-68-5
Synonyms: RH-7281
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Zoxamide (RH-7281) is an oomycete Fungicide and covalent β-tubulin inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici .
Cat. No.: HY-P10785
CAS No.: 83785-07-3
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Cat. No.: HY-120921R
CAS No.: 156052-68-5
Synonyms: RH-7281 (Standard)
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Zoxamide (Standard) is the analytical standard of Zoxamide. This product is intended for research and analytical applications. Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton .
Cat. No.: HY-121801
CAS No.: 84527-51-5
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Zarilamid is a fungicide which is active against a broad spectrum of Oomycete fungi. Zarilamid inhibits nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide inhibits growth of tobacco roots and causes swelling of the root tips, destructs microtubule cytoskeleton and inhibits mitosis .
Cat. No.: HY-182309
CAS No.: 1237645-43-0
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SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. SC83288 disrupts the epigenetic regulation of malaria parasites, blocks DNA replication and nuclear division, arrests the development of the asexual blood stage, induces the formation of pyknotic morphology in malaria parasites, and does not affect cytokinesis after nuclear division or parasite egress. SC83288 is applicable to malaria-related research .
Cat. No.: HY-W714212
CAS No.: 33245-39-5
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Fluchloralin is a dinitroaniline herbicide that effectively controls annual gramineous and broadleaf weeds primarily by inhibiting tubulin synthesis and cell division . Fluchloralin exhibits cytotoxicity and genotoxicity, and promotes cell apoptosis by activating apoptotic signaling proteins, forming DNA ladder bands, inducing cell shrinkage and nuclear fragmentation .
Cat. No.: HY-P811903
Synonyms: RMND5A; Required For Meiotic nuclear division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID Complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic nuclear division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-P3303
CAS No.: 146556-41-4
PF1070A is a Pf HDAC1 inhibitor with an IC50 of 0.0011 μM. By inhibiting histone deacetylase (HDAC) activity, PF1070A induces histone H4 hyperacetylation and chromatin remodeling, arrests cell cycle progression prior to nuclear division, and exhibits antimalarial activity against multidrug-resistant Plasmodium falciparum strains with high selectivity. PF1070A is suitable for use in malaria research .
Cat. No.: HY-W714214
CAS No.: 55283-68-6
Target:
Herbicide Microtubule/Tubulin PI3K Akt Apoptosis Autophagy Reactive Oxygen Species (ROS) NF-κB p38 MAPK
Research Areas:
Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK, inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis, endoplasmic reticulum stress, autophagy, and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis .
Cat. No.: HY-P811903A
Synonyms: RMND5A; Required For Meiotic nuclear division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID Complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic nuclear division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-183955
CAS No.: 2041071-54-7
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GNF7156 is a DYRK1A/GSK3B inhibitor, IC50 values of 100 nM for DYRK1A and 40 nM for GSK3B. GNF7156 inhibits DYRK1A and GSK3B kinase activity and induces NFAT nuclear retention. GNF7156 stimulates beta-cell cycle entry and division and maintains insulin secretory capacity. GNF7156 can be used for the research of type 1 diabetes, and type 2 diabetes .
Cat. No.: HY-187550
CAS No.: 1771650-41-9
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BRD7929 is an orally active phenylalanyl-tRNA synthetase (PheRS) inhibitor and parasiticide, with an IC50 value of 0.023 μM against Plasmodium falciparum PheRS. BRD7929 inhibits the aminoacylation activity of the target enzyme, blocking protein synthesis, DNA replication and parasite nuclear division. BRD7929 clears the asexual blood stage, liver stage and mature gametocyte stage of malaria parasite species, and prevents parasite transmission to mosquitoes. BRD7929 shows moderate cytotoxicity against mammalian cells and inhibits hERG ion channels. BRD7929 achieves cure of malaria in animal models. BRD7929 can be used in research related to cryptosporidiosis and malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
