Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
on
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "on" in MCE Product Catalog:
45
6
Target:
Research Areas:
Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM .
6
6 Cited Publications
Synonyms: on-01910 sodium
Target:
Research Areas:
Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM .
6
4
4 Cited Publications
Target:
Research Areas:
ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity .
2
Narazaciclib (ON123300), a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors . Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM .
2
2
2 Cited Publications
Cat. No.: HY-P701625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KAT8; Protein Acetyltransferase KAT8; Prev. MYST1; FLJ14040; HMOF; ZC2HC8; MOF; MYST-1; Males-Absent on The First Protein Homolog; Ortholog Of Drosophila Males Absent on The First (MOF); MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 1; Probable Histone Acetyltra
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P71094
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SPARC; Basement-Membrane Protein 40; Prev. on; Osteonectin; BM-40; Secreted Protein, Acidic, Cysteine-Rich (Osteonectin); onT; OI17; Secreted Protein Acidic And Rich In Cysteine; Secreted Protein Acidic And Cysteine Rich; Cysteine-Rich Protein
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71381
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TREM2; Trem2b; Triggering Receptor Expressed on Myeloid Cells 2; Trem2c; TREM-2; Triggering Receptor Expressed on Myeloid Cells 2a; Triggering Receptor Expressed on Monocytes 2; PLOSL2; Trem2a; AD17
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71086
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SPARC; Basement-Membrane Protein 40; Prev. on; Osteonectin; BM-40; Secreted Protein, Acidic, Cysteine-Rich (Osteonectin); onT; OI17; Secreted Protein Acidic And Rich In Cysteine; Secreted Protein Acidic And Cysteine Rich; Cysteine-Rich Protein
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P72503
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLRK1; CD314; Prev. D12S2489E; Killer Cell Lectin-Like Receptor Subfamily K, Member 1; NKG2D; NKG2-D-Activating NK Receptor; NKG2-D Type II Integral Membrane Protein; DNA Segment on Chromosome 12 (Unique) 2489 Expressed Sequence; NK Cell Receptor D; Kille
Species:
Mouse
Source:
HEK293
Cat. No.: HY-E70313
Synonyms: Candida antarctica lipase B
Target:
Research Areas:
Lipase,Candida antarctica (Immobilized on hydrophilic carrier) (Candida antarctica lipase B) is a lipase derived from Candida antarctica and immobilized on a hydrophilic carrier. Lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a green catalyst that can be used to catalyze polymer synthesis .
Cat. No.: HY-W048457
CAS No.: 12135-22-7
Synonyms: Pearlman's Catalyst (contains Pd, PdO) (wetted with ca. 55% Water)
Target:
Research Areas:
Palladium hydroxide on activated carbon(20%)(wetted with ca. 55% Water) is a biological molecule.
Cat. No.: HY-16366
CAS No.: 865783-99-9
Synonyms: on 014185
Research Areas:
Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors .
Synonyms: 108600
Research Areas:
ON 108600 (108600) is a CK2 (CK2α1: IC50 = 50 nM; CK2α2 = 5 nM), TNIK (IC50 = 5 nM) and DYRK (DYRK1A: IC50 = 16 nM; DYRK1B = 7 nM; DYRK2: = 28 nM). ON 108600 suppresses the growth of CD44high/CD24low breast cancer stem cell (BCSC) populations, induces G2/M arrest and apoptosis in triple negative breast cancer (TNBC) cells, and inhibits tubulin polymerization. ON 108600 can be used for the study of chemotherapy-resistant and metastatic TNBC .
Cat. No.: HY-164393
CAS No.: 1035199-04-2
ON044580 is a non–ATP-competitive JAK2 and BCR-ABL kinases inhibitor. ON044580 inhibits wild-type (WT) and V617F mutant JAK2 with IC50 values of 1.23 μM, 1.09 μM, respectively. ON044580 also inhibits both WT and T315I mutant BCR-ABL kinases., ON044580 blocks the IL-3–mediated phosphorylation of JAK2 and STAT5, induces apoptosis in Imatinib (HY-15463)-resistant chronic myeloid leukemia (CML). ON044580 can be used for the study of CML, myelodysplasia (MDS) and other myeloproliferative neoplasms .
Cat. No.: HY-E70312
Target:
Research Areas:
High-efficiency lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
Cat. No.: HY-78883
CAS No.: 592542-50-2
Target:
Research Areas:
ON 01500 is a tubulin inhibitor with a Kd of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
