40 Results for "

oxygen consumption

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "oxygen consumption" in MCE Product Catalog:

80
GSK2795039
GSK2795039
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80 Publications Verification
Cat. No.: HY-18950
CAS No.: 1415925-18-6
Target:  

NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis

Research Areas:  

Cancer

GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .
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Phenylarsine oxide
Phenylarsine oxide
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2 Cited Publications
Cat. No.: HY-131901
CAS No.: 637-03-6
Purity:  99.32%
Synonyms: Oxophenylarsine; PhAsO; Arsenosobenzene
Target:  

Environmental Pollutants Phosphatase

Research Areas:  

Others

Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization .
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KPLH1130
KPLH1130
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2 Cited Publications
Cat. No.: HY-128578
CAS No.: 906669-07-6
Purity:  99.86%
Target:  

PDHK NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase

Research Areas:  

Metabolic Disease Inflammation/Immunology

KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions .
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2,6-Dichlorophenolindophenol sodium hydrate
2,6-Dichlorophenolindophenol sodium hydrate
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1 Cited Publications
Cat. No.: HY-W129633
CAS No.: 1266615-56-8
Synonyms: DCIP sodium hydrate; DPIP sodium hydrate
2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae .
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MS-L6
MS-L6
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1 Cited Publications
Cat. No.: HY-158421
CAS No.: 63498-32-8
Purity:  99.95%
Target:  

Oxidative Phosphorylation Mitochondrial Metabolism ATP Synthase Reactive Oxygen Species (ROS) Parasite

Research Areas:  

Infection Cancer

MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma .
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2,5-Anhydro-D-mannitol, 97%
2,5-Anhydro-D-mannitol, 97%
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Cat. No.: HY-W039315
CAS No.: 41107-82-8
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .
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Landiolol hydrochloride
Landiolol hydrochloride
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Cat. No.: HY-100607A
CAS No.: 144481-98-1
Purity:  99.65%
Synonyms: ONO1101 hydrochloride
Target:  

Adrenergic Receptor Calcium Channel Potassium Channel Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Endocrinology

Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury .
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Flutolanil
Flutolanil
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Cat. No.: HY-B2011
CAS No.: 66332-96-5
Target:  

Environmental Pollutants Succinate Dehydrogenase Fungal Mitochondrial Metabolism

Research Areas:  

Infection

Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control .
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KF-52
KF-52
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Cat. No.: HY-170404
CAS No.: 3104612-74-7
Target:  

Phosphatase

Research Areas:  

Metabolic Disease

KF-52 is a phosphofructokinase-1 (PFK1) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction .
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Pentyl 4-hydroxybenzoate
Pentyl 4-hydroxybenzoate
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Cat. No.: HY-W267444
CAS No.: 6521-29-5
Synonyms: Amylparaben
Target:  

Bacterial

Research Areas:  

Infection

Pentyl 4-hydroxybenzoate (Amylparaben) is a type of paraben compound commonly used as a preservative, it has antibacterial properties and is related to the inhibition of induced oxygen consumption .
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SCAL-255
SCAL-255
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Cat. No.: HY-155554
CAS No.: 2798953-61-2
Purity:  99.15%
Target:  

Mitochondrial Metabolism Oxidative Phosphorylation Reactive Oxygen Species (ROS) MMP

Research Areas:  

Cancer

SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces reactive oxygen species (ROS) production, and reduces MMP. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc .
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AMPK activator 13
AMPK activator 13
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Cat. No.: HY-155363
Purity:  99.39%
Target:  

AMPK

Research Areas:  

Metabolic Disease

AMPK activator 13 is a potent activator of AMPK. AMPK activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .
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5-Bromo-5-nitro-1,3-dioxane
5-Bromo-5-nitro-1,3-dioxane
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Cat. No.: HY-W014316
CAS No.: 30007-47-7
Target:  

Bacterial Fungal

Research Areas:  

Infection

5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
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Solenopsin
Solenopsin
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Cat. No.: HY-16461
CAS No.: 137038-57-4
Synonyms: (-)-Solenopsin A
Category:  

Alkaloids Piperidine Alkaloids Microorganisms

Target:  

Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism

Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC50 of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases .
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Saviprazole
Saviprazole
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Cat. No.: HY-101646
CAS No.: 121617-11-6
Purity:  96.05%
Synonyms: HOE-731
Target:  

Proton Pump

Research Areas:  

Inflammation/Immunology

Saviprazole (HOE-731) is a H +,K +-ATPase inhibitor. Saviprazole inhibits gastric acid secretion. Saviprazole inhibits histamine- and dbcAMP-stimulated [ 14C]aminopyrine uptake, dbcAMP-induced oxygen consumption. Saviprazole can be used in research related to gastrointestinal diseases, such as gastric ulcers and acid reflux .
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Ppc-1
Ppc-1
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Cat. No.: HY-117843
CAS No.: 1245818-17-0
Target:  

Mitochondrial Metabolism Interleukin Related Bacterial

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology

Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .
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BJH-86
BJH-86
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Cat. No.: HY-178987
CAS No.: 3067849-10-6
Target:  

Mitochondrial Metabolism Phosphodiesterase (PDE)

Research Areas:  

Cancer

BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer .
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Borapetoside E
Borapetoside E
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Cat. No.: HY-N2953
CAS No.: 151200-49-6
Category:  

Natural Products Menispermaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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