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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
p-Tyr705
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "p-Tyr705" in MCE Product Catalog:
1
1 Cited Publications
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers .
Cat. No.: HY-169797
CAS No.: 3033049-16-7
STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells .
Cat. No.: HY-189693
CAS No.: 459193-26-1
Target:
Research Areas:
c-Met/STAT3-IN-2 is a c-Met and STAT3 inhibitor with IC50 values of 0.20 μM and 0.74 μM, respectively. c-Met/STAT3-IN-2 inhibits c-Met and STAT3 phosphorylation, binds to the STAT3 SH2 domain, and blocks pTyr705 recognition. c-Met/STAT3-IN-2 induces cancer cell apoptosis (apoptosis) and G2/M phase arrest, upregulates P53, Bax, PUMA, caspases-3, -8, and -9, and downregulates Bcl-2. c-Met/STAT3-IN-2 has broad-spectrum anticancer activity, inhibits cancer cell proliferation, and exhibits lethal activity against various cancer cell lines. c-Met/STAT3-IN-2 shows minimal off-target inhibition of STK3, STK4, PI3Kdelta, and VEGFR3. c-Met/STAT3-IN-2 can be used for research related to colorectal cancer, leukemia, non-small cell lung cancer, and breast cancer cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
