71

Ipatasertib

71 Publications Verification

Cat. No.: HY-15186

CAS No.: 1001264-89-6

Purity: 99.79%

Synonyms: GDC-0068; RG7440

Target:

Organoid Akt Apoptosis

Research Areas:

Cancer

Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

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64

Lenalidomide

64 Cited Publications

Cat. No.: HY-A0003

CAS No.: 191732-72-6

Synonyms: CC-5013

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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64

Lenalidomide hemihydrate

64 Cited Publications

Cat. No.: HY-A0003B

CAS No.: 847871-99-2

Synonyms: CC-5013 hemihydrate

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Lenalidomide hemihydrate (CC-5013 hemihydrate) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hemihydrate induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hemihydrate promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hemihydrate can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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52

Idasanutlin

52 Cited Publications

Cat. No.: HY-15676

CAS No.: 1229705-06-9

Purity: 99.93%

Synonyms: RG7388

Target:

MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Pyroptosis Reactive Oxygen Species (ROS) Caspase

Research Areas:

Neurological Disease Cancer

Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC₅₀ of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors .

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27

Beta-Sitosterol (purity>80%)

27 Cited Publications

Cat. No.: HY-N0171

CAS No.: 83-46-5

Category:

Endogenous metabolite

Target:

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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27

Beta-Sitosterol (purity>98%)

27 Cited Publications

Cat. No.: HY-N0171A

CAS No.: 83-46-5

Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)

Category:

Steroids

Target:

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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14

CBL0137 hydrochloride

14 Cited Publications

Cat. No.: HY-18935A

CAS No.: 1197397-89-9

Synonyms: Curaxin-137 hydrochloride; CBL-C137 hydrochloride

Target:

MDM-2/p53 NF-κB

Research Areas:

Cancer

CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC₅₀s of 0.37 and 0.47 μM, respectively.

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14

CBL0137

14 Cited Publications

Cat. No.: HY-18935

CAS No.: 1197996-80-7

Synonyms: Curaxin 137; CBL-C137

Target:

Histone Acetyltransferase MDM-2/p53 NF-κB

Research Areas:

Cancer

CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-κB and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis .

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9

Quinacrine dihydrochloride

9 Cited Publications

Cat. No.: HY-13735A

CAS No.: 69-05-6

Purity: 99.38%

Synonyms: Mepacrine dihydrochloride; SN-390 dihydrochloride

Target:

Parasite Apoptosis Autophagy Mitophagy

Research Areas:

Infection Cancer

Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis .

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9

Quinacrine hydrochloride hydrate

9 Cited Publications

Cat. No.: HY-13735B

CAS No.: 6151-30-0

Purity: 98.05%

Synonyms: Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate

Target:

Parasite Apoptosis Autophagy Mitophagy

Research Areas:

Infection Cancer

Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis .

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8

NSC697923

8 Cited Publications

Cat. No.: HY-13811

CAS No.: 343351-67-7

Purity: 99.93%

Target:

E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity .

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8

Fenbendazole

8 Cited Publications

Cat. No.: HY-B0413

CAS No.: 43210-67-9

Target:

Parasite HIF/HIF Prolyl-Hydroxylase Microtubule/Tubulin Antibiotic

Research Areas:

Infection Cancer

Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .

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7

C16-Ceramide (d18:1/16:0)

7 Cited Publications

Cat. No.: HY-100354

CAS No.: 24696-26-2

Purity: ≥98.0%

Synonyms: C16-Ceramide

Category:

Alkaloids Other Alkaloids Endogenous metabolite Disease Research Fields Cancer

Target:

MDM-2/p53 Apoptosis Endogenous Metabolite

C16-Ceramide (d18:1/16:0) is a natural small molecule activating p53 through the direct and selective binding .

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7

Cyclopiazonic acid

7 Cited Publications

Cat. No.: HY-N6771

CAS No.: 18172-33-3

Category:

Alkaloids Microorganisms Pyrrole Alkaloids Other Diseases Disease Research Fields Indole Alkaloids

Target:

Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

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7

Flubendazole

7 Cited Publications

Cat. No.: HY-B0294

CAS No.: 31430-15-6

Target:

Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy

Research Areas:

Infection Cancer

Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .

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6

MI-773

6 Cited Publications

Cat. No.: HY-17493

CAS No.: 1303607-07-9

Target:

MDM-2/p53 Apoptosis

Research Areas:

Neurological Disease Cancer

MI-773 is an orally active, selective MDM2-p53 interaction inhibitor with a K_i of 0.88 nM for MDM2. MI-773 blocks the MDM2-TP53 interaction. MI-773 potently activates p53. MI-773 induces Apoptosis. MI-773 causes tumor regression in xenograft models of adenoid cystic carcinoma. MI-773 exhibits anticancer effects in neuroblastoma. MI-773 TFA can be used for the research of adenoid cystic carcinoma .

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6

MI-773 TFA

6 Cited Publications

Cat. No.: HY-17493A

CAS No.: 1303609-37-1

Target:

MDM-2/p53 Apoptosis

Research Areas:

Neurological Disease Cancer

MI-773 TFA is an orally active, selective MDM2-p53 interaction inhibitor with a K_i of 0.88 nM for MDM2. MI-773 TFA blocks the MDM2-TP53 interaction. MI-773 TFA potently activates p53. MI-773 TFA induces Apoptosis. MI-773 TFA causes tumor regression in xenograft models of adenoid cystic carcinoma. MI-773 TFA exhibits anticancer effects in neuroblastoma. MI-773 TFA can be used for the research of adenoid cystic carcinoma .

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