6 Results for "

perivascular

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "perivascular" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N0352
CAS No.: 6879-01-2
Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP + reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent .
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Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions . Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia .
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Cat. No.: HY-P10934
CAS No.: 1095009-44-1
Synonyms: LXY2
Target:  

Integrin

Research Areas:  

Cancer

LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer .
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Cat. No.: HY-175660
Target:  

Heme Oxygenase (HO)

Research Areas:  

Cancer

KCL-HO-1i is an orally active heme oxygenase-1 (HO-1) inhibitor (rat HO-1: IC50 = 123 nM) and human HO-1: IC50 = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 + perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer .
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Cat. No.: HY-B0010C
CAS No.: 67346-48-9
Synonyms: (+)-Formoterol
(S,S)-Formoterol ((+)-Formoterol) is the (S,S)-enantiomer of Formoterol (HY-B0010B). (S,S)-Formoterol is a β2-adrenergic receptor (β2-adrenergic receptor) ligand. (S,S)-Formoterol can induce mast cell mediator release, peribronchial and perivascular inflammatory cell infiltration, basal airway tone, IFN-γ production, and IL-4 production. (S,S)-Formoterol acts through the β2-adrenergic receptor, altering its transduction pathways and modulating receptor structure and function. (S,S)-Formoterol can be used in the study of asthma .
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Cat. No.: HY-182713
CAS No.: 160953-95-7
Target:  

Tyrosinase

Research Areas:  

Others

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats .
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