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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
75 Results for "
phase II
" in MedChemExpress (MCE) Product Catalog:
Products (75)
75 Results for "phase II" in MCE Product Catalog:
5
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Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer .
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3 Cited Publications
Synonyms: Idronoxil; Dehydroequol; Haginin E
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Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21 WAF1 via a p53 independent manner .
2
2 Cited Publications
Synonyms: L-Sulforaphane
2
2 Cited Publications
Cat. No.: HY-N12445
CAS No.: 19254-30-9
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Cat. No.: HY-142240
CAS No.: 2209104-84-5
Synonyms: HSK16149
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Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC50 of 3.96 nM in rats. Crisugabalin inhibits the binding of [ 3H]gabapentin to the α2δ subunit, reduces calcium influx, decreases neuronal excitability, and impairs nociceptive transmission. Crisugabalin alleviates mechanical allodynia, neuropathic pain and inflammatory pain in rats, and reduces phase II pain behaviors. Crisugabalin can be used in research related to chronic pain, neuropathic pain, diabetic neuropathy, fibromyalgia, inflammatory pain, diabetic peripheral neuropathy and postherpetic neuralgia.
Synonyms: ADT-G-d4
Androsterone glucuronide-d4 (ADT-G-d4) is the deuterated-labeled Androsterone glucuronide (HY-113104). Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne .
Synonyms: Genistein 7-O-glucuronide
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Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism .
Cat. No.: HY-P2961
CAS No.: 50812-37-8
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Glutathione S-transferase is a phase II metabolic enzyme composed of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses multiple catalytic activities, including catalytic detoxification and thiol transfer, as well as molecular chaperone functions. The Glutathione S-transferase isoform GSTP1 is highly expressed in malignant tumors and serves as a tumor biomarker .
Cat. No.: HY-161501
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3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity .
Cat. No.: HY-W721119
CAS No.: 129244-98-0
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16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
Cat. No.: HY-115772
CAS No.: 20525-20-6
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4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer .
Cat. No.: HY-179152
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Apoptosis inducer 54 is an apoptosis inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer .
Cat. No.: HY-126121
CAS No.: 51146-55-5
Synonyms: (±)-2-Hydroxy Ibuprofen
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N6802
CAS No.: 66069-55-4
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Lignans Phenylpropanoids Plants Schisandraceae Extract Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer
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Cat. No.: HY-14955A
CAS No.: 347870-26-2
Synonyms: (Rac)-MB06322; (Rac)-CS-917
(Rac)-Managlinat dialanetil ((Rac)-MB06322) is a compound for the inhibition of type 2 diabetes that is in Phase II clinical trials and works by inhibiting gluconeogenesis.
Cat. No.: HY-E70659
CDK12/CycK Recombinant Human Active Protein Kinase is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of RNA polymerase II (Pol II), thereby regulating different phases of the transcription cycle from transcription initiation to elongation and termination .
Cat. No.: HY-172338
Synonyms: CHZ-N-Glc
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Chlorzoxazone-N-glucuronide is a phase II metabolite of the skeletal muscle relaxant – Chlorzoxazone. Chlorzoxazone-N-glucuronide can be synthesized via glucuronidation of chlorozoxazone by UGT1A9 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
