22

Lenacapavir

22 Publications Verification

Cat. No.: HY-111964

CAS No.: 2189684-44-2

Purity: 98.44%

Synonyms: GS-6207

Target:

HIV

Research Areas:

Infection

Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

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22

Lenacapavir sodium

22 Publications Verification

Cat. No.: HY-111964A

CAS No.: 2283356-12-5

Synonyms: GS-6207 sodium

Target:

HIV

Research Areas:

Infection

Lenacapavir (GS-6207) sodium is an HIV-1 capsid inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

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10

RI-1

10 Cited Publications

Cat. No.: HY-15317

CAS No.: 415713-60-9

Purity: 99.83%

Target:

RAD51

Research Areas:

Cancer

RI-1 is a RAD51 inhibitor, with IC₅₀s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells .

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8

JH-RE-06

8 Cited Publications

Cat. No.: HY-126214

CAS No.: 1361227-90-8

Purity: 99.87%

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_d=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

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7

Psalmotoxin 1

7 Cited Publications

Cat. No.: HY-P1411

CAS No.: 880107-52-8

Synonyms: PcTx1; Psalmopoeus cambridgei toxin-1

Target:

Sodium Channel Apoptosis

Research Areas:

Neurological Disease Cancer

Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .

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7

Psalmotoxin 1 TFA

7 Cited Publications

Cat. No.: HY-P1411A

Synonyms: PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA

Target:

Sodium Channel Apoptosis

Research Areas:

Neurological Disease Cancer

Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .

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3

IL-17A antagonist 1

3 Cited Publications

Cat. No.: HY-101913

CAS No.: 2205034-18-8

Purity: 99.74%

Target:

Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC₅₀ of 1.14 μM and a K_d of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA .

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3

Brophenexin

3 Cited Publications

Cat. No.: HY-139192

CAS No.: 2243506-33-2

Purity: 99.59%

Synonyms: NMDAR/TRPM4-IN-2

Target:

iGluR TRP Channel ERK

Research Areas:

Neurological Disease

Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC₅₀ of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .

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3

Brophenexin free base

3 Cited Publications

Cat. No.: HY-139192A

CAS No.: 1353979-43-7

Purity: 99.24%

Synonyms: NMDAR/TRPM4-IN-2 free base

Target:

iGluR TRP Channel ERK

Research Areas:

Neurological Disease

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC₅₀ of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .

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2

Retro-2

2 Cited Publications

Cat. No.: HY-122571

CAS No.: 1201652-50-7

Purity: ≥98.0%

Target:

Filovirus Parasite Autophagy

Research Areas:

Infection Cancer

Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC₅₀ of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy .

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1

1-Pyrenebutyric acid N-hydroxysuccinimide ester

1 Cited Publications

Cat. No.: HY-W013151

CAS No.: 114932-60-4

Target:

Biochemical Assay Reagents SARS-CoV

Research Areas:

Others

1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry .

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