8

Compound 48/80 trihydrochloride

8 Publications Verification

Cat. No.: HY-130592

CAS No.: 848035-21-2

Purity: 99.95%

Synonyms: C48/80 trihydrochloride

Target:

Phospholipase

Research Areas:

Neurological Disease

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

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2

Dibutyryl-cGMP sodium

2 Cited Publications

Cat. No.: HY-130354

CAS No.: 51116-00-8

Purity: 99.55%

Synonyms: Bt2cGMP sodium

Target:

Potassium Channel

Research Areas:

Cardiovascular Disease

Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ ³H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K ⁺ channels .

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1

N,N-Dimethylsphingosine

1 Cited Publications

Cat. No.: HY-108491

CAS No.: 119567-63-4

Purity: 99.4%

Target:

SphK Apoptosis

Research Areas:

Cancer

N,N-Dimethylsphingosine is a sphingosine kinase inhibitor. N,N-Dimethylsphingosine binds competitively to sphingosine kinase and blocks the conversion of sphingosine to sphingosine-1-phosphate. N,N-Dimethylsphingosine inhibits sphingosine-1-phosphate release and aggregation of platelets, and also exerts pro-apoptotic effects by resetting ceramide/sphingosine-1-phosphate homeostasis. N,N-Dimethylsphingosine can be used in cancer-related research .

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1

tcY-NH2 TFA

1 Cited Publications

Cat. No.: HY-P1263A

CAS No.: 1262750-73-1

Synonyms: (trans-Cinnamoyl)-YPGKF-NH2 TFA

Target:

Protease Activated Receptor (PAR)

Research Areas:

Metabolic Disease Inflammation/Immunology

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH₂-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology .

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1

Thromboxane B2

1 Cited Publications

Cat. No.: HY-113331

CAS No.: 54397-85-2

Purity: ≥99.0%

Target:

Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid .

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1

tcY-NH2

1 Cited Publications

Cat. No.: HY-P1263

CAS No.: 327177-34-4

Synonyms: (trans-Cinnamoyl)-YPGKF-NH2

Target:

Protease Activated Receptor (PAR)

Research Areas:

Metabolic Disease Inflammation/Immunology

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH₂-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology .

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