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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
polyglutamine
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "polyglutamine" in MCE Product Catalog:
7
7 Cited Publications
Cat. No.: HY-P2260
CAS No.: 1423821-88-8
Cat. No.: HY-P2260B
Cat. No.: HY-125172
CAS No.: 300670-16-0
Synonyms: polyglutamine Aggregation inhibitor III
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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Cat. No.: HY-P10818
CAS No.: 274914-75-9
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Cat. No.: HY-P2260C
Cat. No.: HY-P2260A
Target:
Research Areas:
NSC66098 is an RNA-binding agent. NSC66098 binds to expanded CAG repeat RNA containing AA mismatches and inhibits its pathogenic function. NSC66098 protects cells from proteotoxicity induced by polyglutamine aggregates. NSC66098 can be used in research on Huntington's disease and spinocerebellar ataxia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
