111

Cytarabine

111 Publications Verification

Cat. No.: HY-13605

CAS No.: 147-94-4

Purity: 99.98%

Synonyms: Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

Category:

Infection Natural Products Microorganisms Marine natural products Sponge Endogenous metabolite Disease Research Fields

Target:

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus

Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

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74

CX-5461

74 Cited Publications

Cat. No.: HY-13323

CAS No.: 1138549-36-6

Purity: 99.49%

Target:

DNA/RNA Synthesis MDM-2/p53 AMPK Akt Autophagy Apoptosis Checkpoint Kinase (Chk)

Research Areas:

Cancer

CX-5461 is a selective, orally active RNA polymerase I inhibitor. CX-5461 disrupts the formation of the SL1-rDNA complex, thereby blocking the transcription initiation of ribosomal RNA without altering the activity of RNA polymerase II, DNA replication, or protein translation processes. CX-5461 upregulates the expression of p21, MDM2, Sestrin1/2, and phosphorylated AMPKα, and reduces the level of phosphorylated Akt. CX-5461 induces G2/G2/M cell cycle arrest, Autophagy, Apoptosis, and cellular senescence, and activates CHK1, CHK2, and RPA. CX-5461 can be used in research related to osteosarcoma, cervical cancer, hematologic malignancies, high-grade serous ovarian cancer, and solid tumors .

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74

CX-5461 dihydrochloride

74 Cited Publications

Cat. No.: HY-13323A

Purity: 99.41%

Target:

DNA/RNA Synthesis MDM-2/p53 AMPK Akt Autophagy Apoptosis Checkpoint Kinase (Chk)

Research Areas:

Cancer

CX-5461 dihydrochloride is a selective, orally active RNA polymerase I inhibitor. CX-5461 dihydrochloride disrupts the formation of the SL1-rDNA complex, thereby blocking the transcription initiation of ribosomal RNA without altering the activity of RNA polymerase II, DNA replication, or protein translation processes. CX-5461 dihydrochloride upregulates the expression of p21, MDM2, Sestrin1/2, and phosphorylated AMPKα, and reduces the level of phosphorylated Akt. CX-5461 dihydrochloride induces G2/G2/M cell cycle arrest, Autophagy, Apoptosis, and cellular senescence, and activates CHK1, CHK2, and RPA. CX-5461 dihydrochloride can be used in research related to osteosarcoma, cervical cancer, hematologic malignancies, high-grade serous ovarian cancer, and solid tumors .

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55

Favipiravir

55 Cited Publications

Cat. No.: HY-14768

CAS No.: 259793-96-9

Purity: 99.97%

Synonyms: T-705

Target:

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

Research Areas:

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

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55

Baloxavir

55 Cited Publications

Cat. No.: HY-109025A

CAS No.: 1985605-59-1

Purity: 99.68%

Synonyms: Baloxavir acid; S-033447

Target:

Influenza Virus

Research Areas:

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

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51

Ivermectin

51 Cited Publications

Cat. No.: HY-15310

CAS No.: 70288-86-7

Purity: 98.28%

Synonyms: MK-933; CD-5024; K-237

Category:

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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17

Aphidicolin

17 Cited Publications

Cat. No.: HY-N6733

CAS No.: 38966-21-1

Category:

Microorganisms Terpenoids Diterpenoids Disease Research Fields Inflammation/Immunology

Target:

DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus

Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

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17

Cidofovir

17 Cited Publications

Cat. No.: HY-17438

CAS No.: 113852-37-2

Synonyms: GS 0504; HPMPC; (S)-HPMPC

Target:

CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus

Research Areas:

Infection Cancer

Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .

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17

Cidofovir dihydrate

17 Cited Publications

Cat. No.: HY-17438A

CAS No.: 149394-66-1

Synonyms: GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate

Category:

Infection Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite

Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities .

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