Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
proton affinity
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "proton affinity" in MCE Product Catalog:
Cat. No.: HY-W035520
CAS No.: 35369-53-0
Target:
HBED dihydrochloride is an iron-chelating antioxidant. HBED dihydrochloride chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED dihydrochloride donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED dihydrochloride exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED dihydrochloride crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED dihydrochloride reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED dihydrochloride can be used in research on iron overload and traumatic brain injury (TBI) .
Target:
Research Areas:
HBED is an iron-chelating antioxidant. HBED chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED can be used in research on iron overload and traumatic brain injury (TBI) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
