122

PX-478

122 Publications Verification

Cat. No.: HY-10231

CAS No.: 685898-44-6

Purity: ≥98.0%

Target:

HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .

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33

Menadione

33 Cited Publications

Cat. No.: HY-B0332

CAS No.: 58-27-5

Synonyms: Vitamin K3

Category:

Quinones Microorganisms Other Diseases Endogenous metabolite Disease Research Fields Naphthalene Quinones

Target:

Environmental Pollutants Endogenous Metabolite

Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

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26

Z-VAD

26 Cited Publications

Cat. No.: HY-164388

CAS No.: 162852-62-2

Target:

Caspase Apoptosis Autophagy Necroptosis

Research Areas:

Cardiovascular Disease Cancer

Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

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22

5-Aminolevulinic acid hydrochloride

22 Cited Publications

Cat. No.: HY-N0305

CAS No.: 5451-09-2

Synonyms: 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS)

5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

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22

5-Aminolevulinic acid

22 Cited Publications

Cat. No.: HY-W000450

CAS No.: 106-60-5

Synonyms: 5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid

Category:

Cardiovascular Disease Amino acids Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS)

5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and ROS generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

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13

Elrelesertib

13 Cited Publications

Cat. No.: HY-109566

CAS No.: 2089288-03-7

Purity: 99.22%

Synonyms: AZD1390

Target:

ATM/ATR Apoptosis Checkpoint Kinase (Chk)

Research Areas:

Cancer

Elrelesertib (AZD1390) is an orally active, brain-penetrant ATM kinase inhibitor with IC₅₀ values of 0.78 nM. Elrelesertib blocks ATM-dependent DNA damage response, inhibits ATM autophosphorylation and downstream Chk2, Rad50 phosphorylation, and accumulates at DNA breaks. Elrelesertib acts as a radiosensitizer, induces apoptosis, genomic instability, G2-M cell cycle arrest, ROS elevation, and mitochondrial membrane potential alteration. Elrelesertib has low efflux liability against P-gp and BCRP. Elrelesertib can be used for the research of central nervous system malignancies, glioblastoma multiforme, glioma, lung cancer brain metastases, and breast cancer .

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12

Triapine

12 Cited Publications

Cat. No.: HY-10082

CAS No.: 143621-35-6

Purity: 99.78%

Synonyms: 3-AP; PAN-811; OCX191

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

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10

Ethacrynic acid

10 Cited Publications

Cat. No.: HY-B1640

CAS No.: 58-54-8

Synonyms: Etacrynic acid

Target:

Wnt Glutathione S-transferase NF-κB Calcium Channel NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .

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5

SN52

5 Cited Publications

Cat. No.: HY-P3229

CAS No.: 1071173-56-2

Target:

NF-κB

Research Areas:

Cancer

SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .

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3

Serdemetan

3 Cited Publications

Cat. No.: HY-12025

CAS No.: 881202-45-5

Purity: 99.56%

Synonyms: JNJ-26854165

Target:

MDM-2/p53 E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

Serdemetan (JNJ-26854165) is a potent anticancer agent with radiosensitizing activity. Serdemetan exhibits antiproliferative activity in various p53 wild-type tumor cells. Serdemetan also antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes .

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3

Ro 90-7501

3 Cited Publications

Cat. No.: HY-103241

CAS No.: 293762-45-5

Purity: 99.10%

Target:

Amyloid-β ATM/ATR Phosphatase Apoptosis

Research Areas:

Neurological Disease Cancer

Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

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1

HA-9104

1 Cited Publications

Cat. No.: HY-160799

CAS No.: 2412367-83-8

Target:

E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells .

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1

MKI-1

1 Cited Publications

Cat. No.: HY-137552

CAS No.: 1190277-80-5

Purity: 98.13%

Synonyms: MASTL Kinase Inhibitor-1

Target:

MASTL

Research Areas:

Cancer

MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC₅₀ of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer .

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Cetuximab MMAE

Cat. No.: HY-171135

Target:

Antibody-Drug Conjugates (ADCs) EGFR

Research Areas:

Cancer

Cetuximab MMAE is an antibody-drug conjugate (ADC) targeting EGFR, formed by the random conjugation of the Cetuximab (HY-P9905) antibody and VcMMAE (HY-15575) via reduced interchain cysteines. Cetuximab MMAE binds to EGFR, blocks ligand interactions, inhibits downstream signal transduction, mediates receptor internalization, and delivers MMAE to induce G₂/M phase cell cycle arrest, inhibit microtubule polymerization, interfere with mitosis, and exert radiosensitizing effects. Cetuximab MMAE limits the toxicity of free MMAE to EGFR-expressing cells and circumvents EGFR resistance mechanisms. Cetuximab MMAE is applicable to research related to EGFR ⁺ tumors .

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Enterolactone

Cat. No.: HY-108692

CAS No.: 78473-71-9

Category:

Human Gut Microbiota Metabolites Microorganisms Lignans Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer

Target:

Apoptosis Endogenous Metabolite

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

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Duligotuzumab

Cat. No.: HY-P99866

CAS No.: 1314238-96-4

Synonyms: MEHD-7945A; RG 7597

Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody targeting EGFR. Duligotuzumab blocks the binding of ligands to these two receptors, inhibits downstream HER/ErbB, AKT and MAPK signaling pathways, induces antibody-dependent cellular cytotoxicity, reduces the proliferation and migration abilities of cancer cells, promotes apoptosis, exerts radiosensitizing effects, and reverses EGFR resistance in cancer cells. Duligotuzumab can be used in tumor-related research .

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WSD0628

Cat. No.: HY-162002

CAS No.: 2765448-96-0

Target:

ATM/ATR

Research Areas:

Cancer

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect .

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AZ31

Cat. No.: HY-112198

CAS No.: 2088113-98-6

Purity: 98.13%

Target:

ATM/ATR

Research Areas:

Cancer

AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC₅₀ of <1.2 nM for ATM enzyme, and an IC₅₀ of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer .

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