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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
redox-active
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "redox-active" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: Pyocyanine; Sanazin; Sanasin
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1
1 Cited Publications
Synonyms: Tetrahydroxy-1,4-benzoquinone; Tetrahydroxybenzoquinone
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Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .
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1 Cited Publications
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Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
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1 Cited Publications
Cat. No.: HY-B1106A
CAS No.: 1215458-51-7
Synonyms: Tetrahydroxy-1,4-benzoquinone monohydrate; Tetrahydroxybenzoquinone monohydrate
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Tetrahydroxyquinone monohydrate (Tetrahydroxy-1,4-benzoquinone monohydrate), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone monohydrate can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .
Cat. No.: HY-W012145
CAS No.: 637-01-4
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TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases . TMPD dihydrochloride is also a complex IV substrate .
Cat. No.: HY-W010323
CAS No.: 615-94-1
Synonyms: DHBQ
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2,5-Dihydroxy-1,4-benzoquinone (DHBQ) is a redox-active quinone-based organic ligand with antibacterial activity that can be obtained from fungal metabolites. After 2,5-Dihydroxy-1,4-benzoquinone is incorporated into the Fe (dhbq) metal-organic framework, a two-electron redox process occurs, which helps improve the discharge capacity of Li +-ion battery cathodes. 2,5-Dihydroxy-1,4-benzoquinone can be used to construct conductive metal-organic frameworks suitable for Li +-ion battery cathodes .
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DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
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EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .
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Cat. No.: HY-125662A
CAS No.: 1379783-91-1
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BMX-001 is a blood-brain barrier-penetrant, redox-active manganese porphyrin SOD mimetic with reactive oxygen species/reactive nitrogen species scavenging activity. BMX-001 inhibits NF-κB through S-glutathionylation, activates Nrf2/Keap1, and decreases TRPV1. BMX-001 enhances glucose-stimulated insulin secretion and inhibits islet apoptosis. BMX-001 radiosensitizes tumors, reduces cancer-associated fibroblasts, promotes dendritic cell maturation, modulates macrophage/MDSC/T cell responses, inhibits EMT/angiogenesis/hypoxia/inflammation, and induces apoptosis. BMX-001 protects glial cells while exerting pro-oxidant effects in cancer, and alleviates neuropathic pain. BMX-001 has neuroprotective effects in ischemic stroke. BMX-001 can be used for research on type 1 diabetes, ischemic stroke, pain, breast cancer, and glioblastoma .
Cat. No.: HY-148766
CAS No.: 37648-76-3
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VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule .
Cat. No.: HY-111278R
CAS No.: 85-66-5
Synonyms: Pyocyanine (Standard); Sanazin (Standard); Sanasin (Standard)
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Cat. No.: HY-153978
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GLX481369 is a redox active substance. GLX481369 is a Nox4 inhibitor. GLX481369 has antioxidant effects .
Cat. No.: HY-115832
CAS No.: 79514-49-1
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Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .
Cat. No.: HY-E71617
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2-Phospho-L-lactate guanylyltransferase (EC 2.7.7.68) is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria.
Cat. No.: HY-E71618
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2-Phospho-L-lactate transferase (EC 2.7.8.28) is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria.
Cat. No.: HY-W585926
CAS No.: 56524-76-6
Cat. No.: HY-114243A
CAS No.: 1382469-40-0
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Neurological Disease Inflammation/Immunology Endocrinology Cancer
DpC hydrochloride is a selective, orally active iron chelator with anticancer activity. DpC hydrochloride acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC hydrochloride induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC hydrochloride inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC hydrochloride is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
