Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
retinal explants
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "retinal explants" in MCE Product Catalog:
Cat. No.: HY-190499
Target:
Parasite NOD-like Receptor (NLR) Interleukin Related Caspase TNF Receptor Reactive Oxygen Species (ROS)
Research Areas:
Anti-inflammatory agent 128 is a 2-azido-3-O-benzyl-2-deoxy sp 2-iminosugar glycolipid with anti-inflammatory, antitumor, and antiparasitic activities. Anti-inflammatory agent 128 exhibits broad-spectrum antiproliferative activity against multiple human tumor cell lines. Anti-inflammatory agent 128 elevates mitochondrial ROS levels in Leishmania donovani promastigotes. Anti-inflammatory agent 128 inhibits the inflammatory response of Bv.2 microglia under LPS stimulation, suppresses NLRP3 inflammasome activation, downregulates the pro-inflammatory mediators Tnfa, Il1β, and Il6, and upregulates Hmox1. Anti-inflammatory agent 128 attenuates reactive gliosis in isolated retinal explants from diabetic rats and ameliorates inflammation-related phenotypes associated with diabetic retinopathy. Anti-inflammatory agent 128 can be used in research on tumors, leishmaniasis, and diabetic retinopathy .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
