51

51 Publications Verification

Synonyms: DHA; Cervonic acid

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Cardiovascular System Disorder

Target:

Endogenous Metabolite

Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

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17

Eriodictyol

17 Cited Publications

Cat. No.: HY-N0637

CAS No.: 552-58-9

Synonyms: Huazhongilexone

Category:

Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Melanocortin Receptor TRP Channel

Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC₅₀=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .

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3

All-trans-retinal

3 Cited Publications

Cat. No.: HY-W004500

CAS No.: 116-31-4

Category:

Human Gut Microbiota Metabolites Microorganisms Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis

All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

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3

DL-AP5

3 Cited Publications

Cat. No.: HY-100714

CAS No.: 76326-31-3

Purity: ≥98.0%

Synonyms: 2-APV; DL-2-Amino-5-phosphonovaleric acid

Target:

iGluR

Research Areas:

Neurological Disease Inflammation/Immunology

DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .

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3

DL-AP5 sodium

3 Cited Publications

Cat. No.: HY-100714C

CAS No.: 1303993-72-7

Purity: 99.20%

Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium

Target:

iGluR

Research Areas:

Neurological Disease Inflammation/Immunology

DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .

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1

Calcium dobesilate

1 Cited Publications

Cat. No.: HY-111603

CAS No.: 20123-80-2

Purity: 99.82%

Target:

Apoptosis

Research Areas:

Metabolic Disease Inflammation/Immunology

Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC₅₀ of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions .

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1

Ranirestat

1 Cited Publications

Cat. No.: HY-15314

CAS No.: 147254-64-6

Purity: 96.10%

Synonyms: AS-3201

Target:

Aldose Reductase

Research Areas:

Neurological Disease Metabolic Disease

Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC₅₀s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a K_i of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .

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Perfluorodecalin

Cat. No.: HY-108298

CAS No.: 306-94-5

Purity: ≥98.0%

Synonyms: PP 5; Perfluorodecahydronaphthalene

Target:

Biochemical Assay Reagents

Research Areas:

Neurological Disease

Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears . Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O₂-carrier and used as artificial blood . Perfluorodecalin enhances bone regeneration and cell viability .

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GNE-8505

Cat. No.: HY-114332

CAS No.: 1620573-48-9

Purity: 99.86%

Target:

MAP3K JNK

Research Areas:

Neurological Disease Metabolic Disease

GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 has an IC₅₀ of 0.144 μM for pJNK, and EC₅₀ of 0.457 μM for DRG. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS) .

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