29

PDD 00017273

29 Publications Verification

Cat. No.: HY-108360

CAS No.: 1945950-21-9

Purity: 99.06%

Target:

Poly(ADP-ribose) Glycohydrolase (PARG)

Research Areas:

Cancer

PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC₅₀ of 26 nM, and a K_D of 1.45 nM .

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23

Uridine

23 Cited Publications

Cat. No.: HY-B1449

CAS No.: 58-96-8

Synonyms: β-Uridine

Category:

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Nucleoside Antimetabolite/Analog NF-κB

Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond .

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21

Floxuridine

21 Cited Publications

Cat. No.: HY-B0097

CAS No.: 50-91-9

Synonyms: 5-Fluorouracil 2'-deoxyriboside

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis

Research Areas:

Infection Cancer

Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

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12

Guanosine

12 Cited Publications

Cat. No.: HY-N0097

CAS No.: 118-00-3

Synonyms: DL-Guanosine; Vernine

Category:

Natural Products Anti-aging Endocrine diseases Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Disease Research Fields

Target:

HSV Endogenous Metabolite

Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

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9

Adenosine 5′-diphosphoribose sodium

9 Cited Publications

Cat. No.: HY-100973A

CAS No.: 68414-18-6

Purity: 99.47%

Synonyms: ADP ribose sodium

Target:

TRP Channel Autophagy

Research Areas:

Metabolic Disease Endocrinology Cancer

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .

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9

Adenosine 5′-diphosphoribose

9 Cited Publications

Cat. No.: HY-100973

CAS No.: 20762-30-5

Purity: 98.21%

Synonyms: ADP ribose

Target:

TRP Channel Autophagy

Research Areas:

Neurological Disease Metabolic Disease Cancer

Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .

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8

PARP1 Protein, Human (sf9, His)

8 Cited Publications

Cat. No.: HY-P74652

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: PARP1; NAD(+) ADP-Ribosyltransferase 1; Prev. ADPRT; Poly[ADP-ribose] Synthase 1; Prev. PPOL; ADPRT 1; ARTD1; PARP-1; Poly-PARP; ADP-Ribosyltransferase NAD(+); PARS; NAD(+) ADP-Ribosyltransferase; PARP; Poly(ADP-Ribosyl)Transferase; ADP-Ribosyltransferase

Species:

Human

Source:

Sf9 insect cells

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7

Sulfo-ara-F-NMN

7 Cited Publications

Cat. No.: HY-129522

CAS No.: 1374663-29-2

Purity: 99.18%

Synonyms: CZ-48

Target:

Toll-like Receptor (TLR)

Research Areas:

Neurological Disease

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .

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5

D-Ribose(mixture of isomers)

5 Cited Publications

Cat. No.: HY-W018772

CAS No.: 50-69-1

Category:

Microorganisms Endogenous metabolite Disease Research Fields Saccharides Cancer

Target:

Endogenous Metabolite

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

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5

Macozinone

5 Cited Publications

Cat. No.: HY-12903

CAS No.: 1377239-83-2

Purity: 98.46%

Synonyms: PBTZ169

Target:

Bacterial Antibiotic

Research Areas:

Infection

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect .

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5

BSJ-4-116

5 Cited Publications

Cat. No.: HY-139039

CAS No.: 2519823-34-6

Purity: 98.73%

Target:

PROTACs CDK

Research Areas:

Cancer

BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC₅₀ of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162) .

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