76

SHP099

76 Publications Verification

Cat. No.: HY-100388

CAS No.: 1801747-42-1

Purity: 99.81%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

SHP099 is an allosteric SHP2 inhibitor, with IC₅₀s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2 ^D61Y, SHP2E69K, SHP2 ^A72V, SHP2 ^E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC₅₀: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth ^[2].

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76

SHP099 monohydrochloride

76 Publications Verification

Cat. No.: HY-100388A

CAS No.: 2200214-93-1

Purity: 99.87%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC₅₀ of 70 nM .

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52

Idasanutlin

52 Cited Publications

Cat. No.: HY-15676

CAS No.: 1229705-06-9

Purity: 99.93%

Synonyms: RG7388

Target:

MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Pyroptosis Reactive Oxygen Species (ROS) Caspase

Research Areas:

Neurological Disease Cancer

Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC₅₀ of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors ^[2] .

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23

Ellagic acid

23 Cited Publications

Cat. No.: HY-B0183

CAS No.: 476-66-4

Category:

Neurological Disease Anti-aging Plants Other Families Extract Endogenous metabolite Microorganisms Phenols Polyphenols Disease Research Fields Cancer

Target:

Casein Kinase Reactive Oxygen Species (ROS) Endogenous Metabolite SHP2

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

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11

RMC-4550

11 Cited Publications

Cat. No.: HY-116009

CAS No.: 2172651-73-7

Purity: 99.56%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC₅₀ of 0.583 nM.

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8

Batoprotafib

8 Cited Publications

Cat. No.: HY-136173

CAS No.: 1801765-04-7

Purity: 99.41%

Synonyms: TNO155

Target:

SHP2 Phosphatase

Research Areas:

Cancer

Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC₅₀=0.011 µM). Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors .

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7

PHPS1

7 Cited Publications

Cat. No.: HY-112368

CAS No.: 314291-83-3

Purity: 99.77%

Target:

SHP2 SHP1 Phosphatase

Research Areas:

Cardiovascular Disease Cancer

PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

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7

PHPS1 sodium

7 Cited Publications

Cat. No.: HY-125108

CAS No.: 1177131-02-0

Purity: 99.93%

Target:

SHP2 SHP1 Phosphatase

Research Areas:

Cardiovascular Disease Cancer

PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

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7

Osunprotafib

7 Cited Publications

Cat. No.: HY-145923

CAS No.: 2489404-97-7

Purity: 99.38%

Synonyms: ABBV-CLS-484

Target:

Phosphatase STAT JAK

Research Areas:

Cancer

Osunprotafib (ABBV-CLS-484) is an orally active and selective active site PTPN1 (IC₅₀: 2.5 nM) and PTPN2(IC₅₀: 1.8 nM) inhibitor. Osunprotafib has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib increases the sensitivity of human cancer cell lines to IFNγ. Osunprotafib generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction ^[2] .

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5

NSC-87877

5 Cited Publications

Cat. No.: HY-18756

CAS No.: 56990-57-9

Target:

SHP2 SHP1 Phosphatase Apoptosis

Research Areas:

Others

NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) ^[2].

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5

NSC-87877 disodium

5 Cited Publications

Cat. No.: HY-18756A

CAS No.: 56932-43-5

Target:

SHP2 SHP1 Phosphatase Apoptosis

Research Areas:

Cancer

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) ^[2].

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3

IACS-13909

3 Cited Publications

Cat. No.: HY-137092

CAS No.: 2160546-07-4

Purity: 99.97%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC₅₀ of 15.7 nM and a K_d of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers .

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1

SHP2-D26

1 Cited Publications

Cat. No.: HY-145162

CAS No.: 2458219-65-1

Purity: 95.83%

Target:

PROTACs SHP2 Apoptosis ERK Bcl-2 Family

Research Areas:

Cancer

SHP2-D26 is a SHP2 PROTAC degrader with DC₅₀ values of 6.0 nM (KYSE520 cells) and 2.6 nM (MV4;11 cells), respectively. SHP2-D26 inhibits ERK phosphorylation, upregulates Bim levels, downregulates Mcl-1 levels, and induces cell cycle arrest and apoptosis. SHP2-D26 can be used in studies related to esophageal cancer, acute myeloid leukemia and non-small cell lung cancer ^[2].

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1

SPI-112

1 Cited Publications

Cat. No.: HY-101964

CAS No.: 1051387-90-6

Purity: 98.01%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively ^[2].

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1

SHP394

1 Cited Publications

Cat. No.: HY-114397

CAS No.: 2055757-40-7

Purity: 99.66%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC₅₀ of 23 nM .

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1

SHP836

1 Cited Publications

Cat. No.: HY-121879

CAS No.: 1957276-35-5

Purity: 99.39%

Target:

SHP2 Phosphatase

Research Areas:

Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2 .

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1

SHP-2 Protein, Human (T253M, Q257L, His)

1 Cited Publications

Cat. No.: HY-P700618

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: PTPN11; Protein Tyrosine Phosphatase Non-Receptor Type 11 Isoform 1; Prev. NS1; Tyrosine-Protein Phosphatase Non-Receptor Type; SH-PTP2; Protein-Tyrosine-Phosphatase; PTP2C; Noonan Syndrome 1; BPTP3; CDNA, FLJ92431; sHP-2; PTPN11 Protein; sHP2; METCDS; SH

Species:

Human

Source:

E. coli

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1

Sitneprotafib

1 Cited Publications

Cat. No.: HY-161952

CAS No.: 2245082-05-5

Synonyms: JAB-3312

Target:

SHP2

Research Areas:

Cancer

Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC₅₀: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model .

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1

PTP Inhibitor IV

1 Cited Publications

Cat. No.: HY-112478

CAS No.: 329317-98-8

Purity: 99.90%

Target:

Phosphatase SHP2

Research Areas:

Cancer

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an ₅₀ of 5.21 μM . PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with ₅₀s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively ^[2].

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