Purity: 99.78%

Category:

Alkaloids Pyrrole Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

BPC 157 is the 15-amino acide fragment of gastric peptide BPC. BPC 157 exhibits wound healing promoting and neuroprotective activity. BPC 157 maintains the integrity of the gastrointestinal mucosa without significant toxicity. BPC 157 acetate counteracts NSAIDs/insulin overdose/copper-induced toxicity. BPC 157 ameliorates specific (over)stimulated/damaged neurotransmitter systems-induced behavioral disorders through serotonergic and dopaminergic systems .

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Isatin

Cat. No.: HY-Y0265

CAS No.: 91-56-5

Synonyms: Indoline-2,3-dione

Category:

Cardiovascular Disease Alkaloids Neurological Disease Plants Other Families Extract Disease Research Fields Indole Alkaloids

Target:

Monoamine Oxidase Apoptosis

Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

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4-Chloro-L-phenylalanine

Cat. No.: HY-W019599

CAS No.: 14173-39-8

Synonyms: L-PCPA

Target:

5-HT Receptor Tryptophan Hydroxylase

Research Areas:

Neurological Disease

4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .

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Lofepramine

Cat. No.: HY-12390

CAS No.: 23047-25-8

Purity: ≥99.0%

Synonyms: Lopramine

Target:

5-HT Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC₅₀s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .

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Dihydroergotoxine mesylate

Cat. No.: HY-B0799

CAS No.: 8067-24-1

Synonyms: Ergoloid mesylates

Target:

GABA Receptor Chloride Channel Adrenergic Receptor Dopamine Receptor Phosphodiesterase (PDE)

Research Areas:

Cardiovascular Disease Neurological Disease

Dihydroergotoxine mesylate (Ergoloid mesylates) is an α-adrenergic blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABA_A receptor associated Cl ^- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity .Dihydroergotoxine mesylate (Ergoloid mesylates) is an α-adrenergic blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABA_A receptor associated Cl ^- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity .

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Latrepirdine dihydrochloride

Cat. No.: HY-14537

CAS No.: 97657-92-6

Purity: 99.65%

Synonyms: Dimebolin dihydrochloride

Target:

Amyloid-β Histamine Receptor Adrenergic Receptor 5-HT Receptor Autophagy

Research Areas:

Neurological Disease Endocrinology

Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

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