83 Results for "

sirtuin

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "sirtuin" in MCE Product Catalog:

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38
OSS_128167
OSS_128167
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38 Publications Verification
Cat. No.: HY-107454
CAS No.: 887686-02-4
Purity:  98.63%
Target:  

Sirtuin HBV

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology Cancer

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .
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23
Suramin sodium salt
Suramin sodium salt
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23 Cited Publications
Cat. No.: HY-B0879A
CAS No.: 129-46-4
Synonyms: Suramin hexasodium salt
Target:  

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:  

Infection Cardiovascular Disease Cancer

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .
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20
UBCS039
UBCS039
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20 Cited Publications
Cat. No.: HY-115453
CAS No.: 358721-70-7
Purity:  98.88%
Target:  

Sirtuin Autophagy

Research Areas:  

Cancer

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM .
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14
Sirtinol
Sirtinol
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14 Cited Publications
Cat. No.: HY-13515
CAS No.: 410536-97-9
Target:  

Sirtuin Autophagy Apoptosis

Research Areas:  

Cancer

Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively .
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10
MC3482
MC3482
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10 Cited Publications
Cat. No.: HY-112587
CAS No.: 2922280-86-0
Purity:  98.58%
Target:  

Sirtuin

Research Areas:  

Cancer

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
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7
SRT 1460
SRT 1460
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7 Cited Publications
Cat. No.: HY-124037
CAS No.: 925432-73-1
Purity:  98.16%
Target:  

Sirtuin

Research Areas:  

Cancer

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues .
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5
SIRT5 inhibitor 1
SIRT5 inhibitor 1
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5 Cited Publications
Cat. No.: HY-112634
CAS No.: 2166487-21-2
Purity:  99.65%
Target:  

Sirtuin

Research Areas:  

Others

SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
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5
SIRT1 Protein, Human (His)
SIRT1 Protein, Human (His)
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5 Cited Publications
Cat. No.: HY-P71596
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT1; sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 1; sirtuin 1; sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S. Cerevisiae); SIR2L1; Protein Acetyllysine N-Acetyltransferase; NAD-Dependent Protein Dea
Species:  
Human
Source:  
E. coli
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4
SRT 2183
SRT 2183
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4 Cited Publications
Cat. No.: HY-19759
CAS No.: 1001908-89-9
Target:  

Sirtuin Apoptosis

Research Areas:  

Cancer

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM . SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .
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4
SIRT1 Antibody (YA082)
SIRT1 Antibody (YA082)
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4 Cited Publications
Cat. No.: HY-P80319
Synonyms: SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2; sirtuin 1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, ChIP

Reactivity:  

Human, Mouse

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3
SIRT4-IN-1
SIRT4-IN-1
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3 Cited Publications
Cat. No.: HY-163316
CAS No.: 3030697-87-8
Target:  

Sirtuin Glutamate Dehydrogenase (GLDH) PDHK

Research Areas:  

Metabolic Disease Cancer

SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD +. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .
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2
2-APQC
2-APQC
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2 Cited Publications
Cat. No.: HY-158426
CAS No.: 500271-63-6
Purity:  99.70%
Target:  

Sirtuin

Research Areas:  

Cardiovascular Disease

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .
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2
SIRT5 Protein, Human (Flag)
SIRT5 Protein, Human (Flag)
0 Images
2 Cited Publications
Cat. No.: HY-P74545
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SIRT5; sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5; sirtuin 5; NAD-Dependent Lysine Demalonylase And Desuccinylase sirtuin-5, Mitochondrial; NAD-Dependent Protein Deacylase sirtuin-5, Mitochondrial; Silent Mating Type In
Species:  
Human
Source:  
E. coli
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1
Sirt2-IN-1
Sirt2-IN-1
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1 Cited Publications
Cat. No.: HY-112427
CAS No.: 1862238-00-3
Purity:  98.71%
Target:  

Sirtuin

Research Areas:  

Inflammation/Immunology Cancer

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM .
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1
E1231
E1231
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1 Cited Publications
Cat. No.: HY-117006
CAS No.: 1031195-19-3
Purity:  98.55%
Synonyms: 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
Target:  

Sirtuin

Research Areas:  

Cardiovascular Disease

E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE -/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .
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1
SIRT6 Antibody (YA078)
SIRT6 Antibody (YA078)
0 Images
1 Cited Publications
Cat. No.: HY-P80322
Synonyms: SIR2L6, SIRT6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6, Protein mono-ADP-ribosyltransferase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, hSIRT6

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, FC

Reactivity:  

Human, Mouse

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SKLB-11A
SKLB-11A
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Cat. No.: HY-173572
CAS No.: 433953-86-7
Target:  

Sirtuin Autophagy

Research Areas:  

Cardiovascular Disease

SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models .
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Suramin
Suramin
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Cat. No.: HY-B0879
CAS No.: 145-63-1
Target:  

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:  

Infection Cardiovascular Disease Cancer

Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .
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Parishin E
Parishin E
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Cat. No.: HY-N2126
CAS No.: 952068-57-4
Category:  

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