151

151 Publications Verification

Synonyms: N-Acetyl-5-methoxytryptamine

Category:

Natural Products Neurological Disease Other disease Anti-aging Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis Ligands for Target Protein for PROTAC Histone Acetyltransferase

Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

40

Levofloxacin hydrochloride

40 Cited Publications

Cat. No.: HY-B0330B

CAS No.: 177325-13-2

Synonyms: (-)-Ofloxacin hydrochloride

Target:

Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Orthopoxvirus Apoptosis

Research Areas:

Infection Neurological Disease Cancer

Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

Ramelteon

13 Cited Publications

Cat. No.: HY-A0014

CAS No.: 196597-26-9

Synonyms: TAK-375

Target:

Melatonin Receptor

Research Areas:

Neurological Disease Endocrinology Cancer

Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Choline chloride

6 Cited Publications

Cat. No.: HY-B1337

CAS No.: 67-48-1

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Histamine Receptor

Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Choline (bitartrate)

6 Cited Publications

Cat. No.: HY-101036

CAS No.: 87-67-2

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids

Target:

Histamine Receptor

Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Choline theophyllinate

6 Cited Publications

Cat. No.: HY-B1718

CAS No.: 4499-40-5

Synonyms: Oxtriphylline

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Histamine Receptor

Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Prostaglandin D2

5 Cited Publications

Cat. No.: HY-101988

CAS No.: 41598-07-6

Purity: 99.5%

Synonyms: PGD2

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Prostaglandin Receptor Endogenous Metabolite

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances . PGD2 plays a protective role by suppressing inflammation .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Butylhydroxyanisole

5 Cited Publications

Cat. No.: HY-B1066

CAS No.: 25013-16-5

Synonyms: Butylated hydroxyanisole; E320

Target:

Environmental Pollutants Reactive Oxygen Species (ROS) Ferroptosis

Research Areas:

Neurological Disease Inflammation/Immunology

Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .

Compare

loading...