14

DOPE

14 Publications Verification

Cat. No.: HY-112005

CAS No.: 4004-05-1

Purity: 98.80%

Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Target:

Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase

Research Areas:

Inflammation/Immunology Cancer

DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .

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12

Echinomycin

12 Cited Publications

Cat. No.: HY-106101

CAS No.: 512-64-1

Purity: 98.57%

Synonyms: Quinomycin A; NSC-13502

Target:

HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial

Research Areas:

Cancer

Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM .

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7

CWP232228

7 Cited Publications

Cat. No.: HY-18959

CAS No.: 1144044-02-9

Target:

β-catenin Wnt

Research Areas:

Cancer

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

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6

SCF Protein, Human

6 Cited Publications

Cat. No.: HY-P70781

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF

Species:

Human

Source:

E. coli

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4

Ki20227

4 Cited Publications

Cat. No.: HY-10408

CAS No.: 623142-96-1

Purity: 99.51%

Target:

c-Fms VEGFR c-Kit PDGFR

Research Areas:

Inflammation/Immunology

Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC₅₀s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .

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4

Tyrphostin AG1296

4 Cited Publications

Cat. No.: HY-13894

CAS No.: 146535-11-7

Purity: 99.69%

Synonyms: AG1296

Target:

PDGFR c-Kit FLT3 Apoptosis

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

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3

PTC-028

3 Cited Publications

Cat. No.: HY-103696

CAS No.: 1782970-28-8

Purity: ≥98.0%

Target:

BMI1 Apoptosis

Research Areas:

Cancer

PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis .

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3

SCF Protein, Mouse

3 Cited Publications

Cat. No.: HY-P70528

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF

Species:

Mouse

Source:

E. coli

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3

SCF Protein, Mouse (HEK293, His)

3 Cited Publications

Cat. No.: HY-P70555

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: KITLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel factor; Mast cell Growth factor; C-Kit Ligand; stem cell factor; Kit Ligand; DFNA69; SHEP7; Kitl; DCUA; KL-1; FPHH; FPH2; WS2F; KIT Ligand; SF

Species:

Mouse

Source:

HEK293

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2

c-Kit Antibody (YA3501)

2 Cited Publications

Cat. No.: HY-P80619

Synonyms: KIT; SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117

Host:

Rabbit

Application:

WB, IHC-P

Reactivity:

Human

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1

Glycylglycine

1 Cited Publications

Cat. No.: HY-D0889

CAS No.: 556-50-3

Synonyms: Gly-Gly; H-Gly-Gly-OH

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

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