7

Mizacorat

7 Publications Verification

Cat. No.: HY-120012

CAS No.: 1893415-00-3

Purity: 99.71%

Synonyms: AZD9567

Target:

Glucocorticoid Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC₅₀ of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation .

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7

GLPG0492

7 Publications Verification

Cat. No.: HY-18102

CAS No.: 1215085-92-9

Target:

Androgen Receptor

Research Areas:

Neurological Disease

GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator. GLPG0492 exerts functional transactivation by binding to the ligand-binding domain of the receptor, exhibiting preferential partial agonist activity in muscle and bone tissues with low activity in reproductive tissues. GLPG0492 effectively counteracts muscle atrophy-related pathways, significantly enhances muscle strength, maintains motor ability, reduces fibrosis and improves electrophysiological parameters. GLPG0492 prevents immobilization-induced muscle atrophy and regulates muscle mass homeostasis, serving as a valuable tool compound for studies on Duchenne muscular dystrophy, muscle loss and various types of disuse musculoskeletal atrophy .

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4

Amcenestrant

4 Cited Publications

Cat. No.: HY-133017

CAS No.: 2114339-57-8

Purity: 99.79%

Synonyms: SAR439859

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

SAR439859 (compound 43d) is an orally active, non-steroidal, and selective estrogen receptor degrader (SERD). SAR439859 is an effective ER antagonist with ER degradation activity, an EC₅₀ of 0.2 nM. SAR439859 can show potent anti-tumor effects and limited cross-resistance in ER ⁺ breast cancer.

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1

Etodolac

1 Cited Publications

Cat. No.: HY-76251

CAS No.: 41340-25-4

Synonyms: AY-24236

Target:

COX

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that can cross the blood-brain barrier and is a non-selective inhibitor of COX (IC₅₀=53.5 nM)

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5α-Cholestan-3β-ol

Cat. No.: HY-107819

CAS No.: 80-97-7

Purity: 99.92%

Synonyms: Dihydrocholesterol; 5α-Cholestanol; NSC 18188

Category:

Other disease Other Diseases Disease markers Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

5α-Cholestan-3β-ol is a derivitized steroid compound.

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Griffonilide

Cat. No.: HY-N0386

CAS No.: 61371-55-9

Category:

Natural Products Other Diseases Plants Other Families Extract Disease Research Fields

Target:

Drug Derivative

Griffonilide is a steroidal compound that can be isolated from the roots of Semiaquilegia adoxoides .

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Pipecuronium bromide

Cat. No.: HY-B0743A

CAS No.: 52212-02-9

Target:

nAChR

Research Areas:

Neurological Disease

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM .

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