10021 Results for "

strong

" in MedChemExpress (MCE) Product Catalog:
Products (10021)

10021 Results for "strong" in MCE Product Catalog:

353
MitoSOX Red
MitoSOX Red
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353 Publications Verification
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.
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262
JC-1
JC-1
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262 Cited Publications
Cat. No.: HY-15534
CAS No.: 3520-43-2
Purity:  98.71%
Synonyms: CBIC2
JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
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131
Methyl-β-cyclodextrin
Methyl-β-cyclodextrin
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131 Cited Publications
Cat. No.: HY-101461
CAS No.: 128446-36-6
Purity:  99.95%
Synonyms: Methyl-beta-cyclodextrin
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .
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93
Calcein-AM
Calcein-AM
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93 Cited Publications
Cat. No.: HY-D0041
CAS No.: 148504-34-1
Synonyms: Calcein acetoxymethyl ester
Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
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80
Colchicine
Colchicine
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80 Cited Publications
Cat. No.: HY-16569
CAS No.: 64-86-8
Category:  

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:  

Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)

Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
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71
PEI Transfection Reagent
PEI Transfection Reagent
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71 Cited Publications
Cat. No.: HY-K2014

MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、HepG2 and HeLa et, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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66
Dimethyl sulfoxide
Dimethyl sulfoxide
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66 Cited Publications
Cat. No.: HY-Y0320C
CAS No.: 67-68-5
Synonyms: DMSO
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity .
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
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61
Cabozantinib
Cabozantinib
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61 Cited Publications
Cat. No.: HY-13016
CAS No.: 849217-68-1
Purity:  99.96%
Synonyms: XL184; BMS-907351
Target:  

VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis

Research Areas:  

Cancer

Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .
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56
QNZ
QNZ
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56 Cited Publications
Cat. No.: HY-13812
CAS No.: 545380-34-5
Purity:  99.50%
Synonyms: EVP4593
Target:  

NF-κB TNF Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.
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56
Doramapimod hydrochloride
Doramapimod hydrochloride
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56 Cited Publications
Cat. No.: HY-10320A
CAS No.: 1283526-53-3
Synonyms: BIRB 796 hydrochloride
Target:  

Autophagy Raf p38 MAPK

Research Areas:  

Inflammation/Immunology

Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases .
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53
Streptomycin
Streptomycin
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53 Cited Publications
Cat. No.: HY-B1906
CAS No.: 57-92-1
Synonyms: Agrept; Agrimycin; Streptomycin A
Category:  

Natural Products Microorganisms

Target:  

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .
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52
DL-Dithiothreitol
DL-Dithiothreitol
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52 Cited Publications
Cat. No.: HY-15917
CAS No.: 3483-12-3
Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .
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51
Edaravone
Edaravone
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51 Cited Publications
Cat. No.: HY-B0099
CAS No.: 89-25-8
Synonyms: MCI-186
Target:  

Free Radical Scavengers MMP Apoptosis

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer

Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
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47
Apilimod
Apilimod
0 Images
47 Cited Publications
Cat. No.: HY-14644
CAS No.: 541550-19-0
Purity:  99.80%
Synonyms: STA 5326; LAM-002A free base; AIT-101
Target:  

Interleukin Related PIKfyve

Research Areas:  

Inflammation/Immunology Cancer

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.
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47
Apilimod mesylate
Apilimod mesylate
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47 Cited Publications
Cat. No.: HY-14644A
CAS No.: 870087-36-8
Purity:  99.83%
Synonyms: STA 5326 mesylate; LAM-002A; AIT-101 mesylate
Target:  

Interleukin Related PIKfyve

Research Areas:  

Inflammation/Immunology Cancer

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.
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47
Dehydrocorydaline chloride
Dehydrocorydaline chloride
0 Images
47 Cited Publications
Cat. No.: HY-N0674A
CAS No.: 10605-03-5
Synonyms: 13-Methylpalmatine chloride
Category:  

Infection Alkaloids Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:  

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
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47
Dehydrocorydaline
Dehydrocorydaline
0 Images
47 Cited Publications
Cat. No.: HY-N0674
CAS No.: 30045-16-0
Synonyms: 13-Methylpalmatine
Category:  

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