42 Results for "

subcapsular cataracts

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "subcapsular cataracts" in MCE Product Catalog:

114
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholate dihydrate
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114 Publications Verification
Cat. No.: HY-19696B
CAS No.: 117609-50-4
Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .
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7
E 2012
E 2012
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7 Cited Publications
Cat. No.: HY-10016
CAS No.: 870843-42-8
Purity:  97.08%
Target:  

γ-secretase

Research Areas:  

Neurological Disease

E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat .
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4
Proparacaine hydrochloride
Proparacaine hydrochloride
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4 Cited Publications
Cat. No.: HY-66012
CAS No.: 5875-06-9
Synonyms: Proxymetacaine hydrochloride
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts .
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2
Bendazac L-Lysine
Bendazac L-Lysine
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2 Cited Publications
Cat. No.: HY-B2165
CAS No.: 81919-14-4
Target:  

Amino Acid Derivatives

Research Areas:  

Others

Bendazac L-Lysine is one of agents that have been introduced for the management of cataracts, protecting the level of vision in patients, thus delaying the need for surgical intervention.
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1
Calpain Inhibitor VI
Calpain Inhibitor VI
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1 Cited Publications
Cat. No.: HY-118933
CAS No.: 190274-53-4
Purity:  ≥95.0%
Synonyms: SJA6017
Target:  

Proteasome

Research Areas:  

Others

Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of calpain. Calpain Inhibitor VI inhibits purified m-calpain with the IC50 of 80 nM. Calpain Inhibitor VI can be used for the research of cataract .
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1
LLL3
LLL3
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1 Cited Publications
Cat. No.: HY-124843
CAS No.: 63972-38-3
Purity:  97.20%
Synonyms: CLT-005
Target:  

STAT Apoptosis Caspase PARP

Research Areas:  

Neurological Disease Metabolic Disease Cancer

LLL3 (CLT-005) is an orally effective STAT3 inhibitor. LLL3 blocks STAT3 dimerization, nuclear translocation, and transcription by binding to the SH2 domain. LLL3 induces apoptosis and PARP/caspase-3 cleavage, thereby inhibiting the proliferation and invasion of cancer cells. LLL3 reduces retinal vascular permeability, pro-angiogenic and pro-inflammatory factor levels, ameliorates diabetes-related vision loss and cataracts, and exhibits good biosafety. LLL3 inhibits tumor growth in vivo. LLL3 can be used in research related to glioblastoma, breast cancer, chronic myeloid leukemia, and diabetic retinopathy .
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N-Acetylcarnosine
N-Acetylcarnosine
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Cat. No.: HY-133026
CAS No.: 56353-15-2
Purity:  99.92%
Synonyms: N-Acetyl-L-carnosine
Target:  

Drug Intermediate Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts .
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Pirenoxine
Pirenoxine
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Cat. No.: HY-108296
CAS No.: 1043-21-6
Purity:  ≥95.0%
Synonyms: Catalin K
Target:  

Biochemical Assay Reagents Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Inflammation/Immunology

Pirenoxine (Catalin K) is an antioxidant with lens-protective activity. Pirenoxine inhibits lens sclerosis, prevents lipid peroxidation and suppresses lens protein opacification. Pirenoxine blocks benzoquinone acetic acid-induced cataract progression. Pirenoxine can be used in research related to presbyopia and cataracts .
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N-Acetylhistidine monohydrate
N-Acetylhistidine monohydrate
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Cat. No.: HY-W014180
CAS No.: 39145-52-3
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

N-Acetylhistidine monohydrate is a compatible osmolyte in the brain, retina, and lens of poikilothermic vertebrates, and binds to E. coli HisJ with a Kd of 27 μM. N-Acetylhistidine monohydrate participates in the regulatory volume decrease process under hypotonic stress, assists cells in restoring homeostatic volume, and acts as a gradient-driven molecular water pump, exerting a protective effect against hypotonic swelling. N-Acetylhistidine monohydrate can be used in combination with glutamate to inhibit the cobalt-resistant postsynaptic component in the electroretinogram. N-Acetylhistidine monohydrate reduces Ca 2+-induced growth inhibition and restores cell growth. N-Acetylhistidine monohydrate can be used in research related to cataracts, diabetic distal symmetric polyneuropathy, and stroke .
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6-Hydroxyluteolin
6-Hydroxyluteolin
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Cat. No.: HY-151231
CAS No.: 18003-33-3
Purity:  98.15%
Target:  

Aldose Reductase

Research Areas:  

Neurological Disease Metabolic Disease

6-Hydroxyluteolin (Compound 17) is a flavonoid derivative and also an inhibitor of Aldose reductase, with an experimental -log IC50 value of 6.690. 6-Hydroxyluteolin can be isolated from the leaves of multiple plant families, including Plantaginaceae, Globulariaceae and Labiatae. 6-Hydroxyluteolin serves as a phylogenetic marker for higher plants. 6-Hydroxyluteolin can be used in the research of diabetic cataract .
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Prednisolone hemisuccinate
Prednisolone hemisuccinate
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Cat. No.: HY-B1087
CAS No.: 2920-86-7
Synonyms: Prednisolone 21-hemisuccinate
Target:  

Glucocorticoid Receptor

Research Areas:  

Neurological Disease

Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a prodrug of Prednisolone (HY-17463) and a glucocorticoid. Prednisolone hemisuccinate converts to Prednisolone in vivo. Prednisolone hemisuccinate induces the inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAP-DH) in vitro. Prednisolone hemisuccinate can be used in research related to cataracts .
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Pentosidine
Pentosidine
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Cat. No.: HY-113033
CAS No.: 124505-87-9
Category:  

Natural Products Disease markers Endogenous metabolite

Target:  

Biochemical Assay Reagents

Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .
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3,5-Dinitrocatechol
3,5-Dinitrocatechol
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Cat. No.: HY-100959
CAS No.: 7659-29-2
Purity:  99.72%
Synonyms: OR-486; 3,5-Dinitropyrocatechol
Target:  

COMT

Research Areas:  

Neurological Disease Endocrinology

3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract .
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Luteolin-3′,7-diglucoside
Luteolin-3′,7-diglucoside
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Cat. No.: HY-N8318
CAS No.: 52187-80-1
Category:  

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