![N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine](https://file.medchemexpress.com/product_pic/hy-154835.gif "Click to View N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
sumoylation
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "sumoylation" in MCE Product Catalog:
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40 Publications Verification
Synonyms: TAK-981
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Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
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Ginkgo biloba L. Extract Plant Monophenols Ginkgoaceae Extract Simple Phenylpropanols Ketones, Aldehydes, Acids Phenols Phenylpropanoids Disease Research Fields Cancer
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12
12 Cited Publications
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2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
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4 Cited Publications
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N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research .
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2 Cited Publications
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COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro .
Cat. No.: HY-Y0493
CAS No.: 28230-32-2
Synonyms: HOOBt
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .
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AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects .
Synonyms: (S)-TAK-981
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(S)-Subasumstat is the isomer of Subasumstat (HY-111789). Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
Cat. No.: HY-123888
CAS No.: 55625-78-0
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H-L-Lys (4-N3-Z)-OH hydrochloride is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. H-L-Lys (4-N3-Z)-OH hydrochloride enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. H-L-Lys (4-N3-Z)-OH hydrochloride serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
Cat. No.: HY-176907
CAS No.: 1858275-91-8
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ML-93 is an orally active SAE inhibitor, with an IC50 value of 0.4 μM. ML-93 inhibits the SUMOylation pathway in HCT116 cells. ML-93 shows robust antitumor activity in the HCT116 colorectal carcinoma xenograft model. ML-93 can be used for the study of colorectal cancer .
Cat. No.: HY-N0077R
CAS No.: 22910-60-7
Synonyms: Ginkgolic acid (15:1) (Standard); Ginkgolic acid I (Standard); Romanicardic acid (Standard)
Category:
Plant Monophenols Ginkgoaceae Extract Ketones, Aldehydes, Acids Phenols Ginkgo biloba L. Extract
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Cat. No.: HY-148835A
Purity: 99.77%
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Cat. No.: HY-145269
CAS No.: 2761538-66-1
AL-GDa62 is a derivative of the CDH1/E-cadherin modulator SLEC-11 (HY-145268) and induces apoptosis in CDH1 -/- cells. AL-GDa62 has an EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild type) and mutant MCF10A-CDH1 -/-, respectively. AL-GDa62 specifically inhibits TCOF1, ARPC5, and UBC9, and suppresses SUMOylation at low micromolar concentrations .
Cat. No.: HY-154835
CAS No.: 1513855-74-7
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N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
Cat. No.: HY-111789R
CAS No.: 1858276-04-6
Synonyms: TAK-981 (Standard)
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Subasumstat (Standard) is the analytical standard of Subasumstat (HY-111789). This product is intended for research and analytical applications. Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
Cat. No.: HY-181772
CAS No.: 315698-78-3
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MCULE-3064932370 is a covalent and allosteric SUMO E1 (heterodimer of Aos1 and Uba2) inhibitor with IC50 values ranging from 16.66 μM to 2.96 μM. MCULE-3064932370 inhibits SUMOylation of Uba2. MCULE-3064932370 has anti-cancer activity against breast cancer .
Cat. No.: HY-110273R
CAS No.: 862974-25-2
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N106 (Standard) is the analytical standard of N106 (HY-110273). This product is intended for research and analytical applications. N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
