18 Results for "

systemic IgG

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "systemic IgG" in MCE Product Catalog:

6
6 Cited Publications
Cat. No.: HY-P9952
CAS No.: 356547-88-1
Synonyms: LymphoStat B
Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
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1 Cited Publications
Cat. No.: HY-P99414
CAS No.: 1523164-68-2
Synonyms: AMG 557
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .
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Cat. No.: HY-P99315
CAS No.: 220651-94-5
Synonyms: BG 9588; Anti-Human CD40L Recombinant Antibody; Hu5c8

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P99220
CAS No.: 1143503-67-6
Synonyms: LY2127399

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus .
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Cat. No.: HY-P9990
CAS No.: 2407378-48-5
Synonyms: BIIB059
Litifilimab (BIIB059) is a humanized IgG1 monoclonal antibody targeting BDCA2. Litifilimab induces internalization of BDCA2 receptors on the membrane of plasmacytoid dendritic cells, inhibits the TLR7/TLR9 signaling pathway, and suppresses the production of type I interferons. Litifilimab can be used in the research of systemic and cutaneous lupus erythematosus .
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Cat. No.: HY-P99358
CAS No.: 1662664-56-3
Synonyms: GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab)

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Dezamizumab (GSK 2398852) is a fully humanized clonal IgG1 antibody against serum amyloid P component (SAP) with complement activation and amyloid clearance-inducing activities. Dezamizumab binds to SAP associated with amyloid deposits to form complexes that activate complement and mediate phagocytic clearance, triggering activation of the classical complement pathway. Dezamizumab can be used for the research of systemic amyloidosis .
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Cat. No.: HY-P99529
CAS No.: 1804910-11-9
Synonyms: BAX1810; TAK-752; SM101

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Valziflocept (BAX1810) is a recombinant soluble human FcγRIIb receptor that targets Fc and FcγR. FcγRs bind to and neutralize pathogenic IgG, thereby acting as a "decoy" or "scavenger" receptor that reduces the severity of autoimmune diseases. Valziflocept is used in research on autoimmune diseases such as systemic lupus erythematosus (SLE) .
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Cat. No.: HY-P990937
CAS No.: 2948444-06-0
Synonyms: PF-04236921; TOUR-006

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Pacibekitug (PF-04236921; TOUR-006) is a fully humanized IgG2 monoclonal antibody targeting IL-6. Pacibekitug binds to and neutralizes IL-6 signaling, thereby inhibiting the pathophysiological role of this pro-inflammatory cytokine in autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus) [1][2].
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Cat. No.: HY-P991271
Synonyms: NNC-114-0005; NN9828; NNC01140006
NN-8828 (NNC-114-0005; NN9828; NNC01140006) is a human IgG1 monoclonal antibody inhibitor targeting IL-21 that binds and neutralizes soluble IL-21 with a Kd of 0.19 pM. NN-8828 restores the balance between effector T cells and regulatory T cells, inhibits pathological antibody production, and alleviates IL-21-mediated inflammatory responses without inducing antibody-dependent cellular cytotoxicity. NN-8828 exhibits favorable biosafety. NN-8828 can be used in research related to rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus .
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Cat. No.: HY-P99267
CAS No.: 948570-30-7
Synonyms: RhuMab IFNalpha; Anti-Human IFN alpha Recombinant Antibody

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Rontalizumab is a humanized IgG1 monoclonal antibody targets IFN-α. Rontalizumab can be used for the research of systemic lupus erythematosus[1].
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Cat. No.: HY-P991051

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

GSK-2330811 is a humanized IgG1 antibody that targets Oncostatin M (OSM). GSK-2330811 has the potential for the study of diffuse cutaneous systemic sclerosis (dcSSc). The isotype control for GSK-2330811 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P99893
CAS No.: 2143449-47-0
Synonyms: AMG 570
Target:  

CD28 TNF Receptor

Research Areas:  

Inflammation/Immunology

Rozibafusp alfa (AMG 570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Rozibafusp alfa can be used for the research of systemic lupus erythematosus and other autoimmune diseases .
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Cat. No.: HY-P991039
CAS No.: 2937458-25-6
Synonyms: AT-02

Target:  

Amyloid-β

Research Areas:  

Inflammation/Immunology

Zamubafusp alfa (AT-02) is an immunoglobulin-peptide fusion protein consisting of a humanized IgG1 and the pan-amyloid reactive peptide p5R. Zamubafusp alfa binds to two ubiquitous components of all amyloids, namely amyloid fibrils and highly sulfated heparan sulfate glycans. Zamubafusp alfa enhances macrophage phagocytosis for amyloid clearance and can be used in research related to systemic amyloidosis .
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Cat. No.: HY-P991510

Target:  

TNF Receptor

Research Areas:  

Cancer

CDX-1140 is a fully human IgG monoclonal antibody and CD40 agonist, with a Kd value of 0.01 nM against human targets. The epitope of CDX-1140 locates at CD40 CRD1 and avoids the CD40L binding site. It activates DCs and B cells, drives NF-κB reporter gene activation, exhibits agonist activity independent of FcR cross-linking, and shows a synergistic effect with recombinant CD40L . CDX-1140 does not induce systemic cytokine release, exerts direct and immune-mediated anti-tumor activity in tumor xenografts, and has favorable safety profiles. When used as a local vaccine adjuvant in combination with 6MHP+mBRAF+poly-ICLC, CDX-1140 increases the number of DC-LAMP + DCs and induces Th1 CD4 + responses in high-risk melanoma. CDX-1140 can be used in studies related to B-cell lymphoma, bladder cancer and high-risk melanoma .
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Cat. No.: HY-123013
CAS No.: 53944-40-4
Research Areas:  

Inflammation/Immunology

Y 9000 is an orally active antiallergic and anti-inflammatory compound. Y 9000 targets mast cells, inhibits the release of allergic mediators, stimulates the adrenal glands, exhibits glucocorticoid-like activity, and reduces adrenal ascorbic acid content. Y 9000 inhibits IgE-mediated and IgG-mediated allergic reactions as well as active systemic anaphylaxis in mice. Y 9000 inhibits allergic wheezing in passively sensitized guinea pigs and protects against active systemic anaphylactic shock in mice. Y 9000 inhibits non-immune responses in rats, including dextran-induced histamine release, anaphylactoid reactions and paw swelling. Y 9000 can be used in the research of allergic diseases (asthma, allergic rhinitis, urticaria, etc.) .
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Cat. No.: HY-129442
CAS No.: 185915-32-6
Synonyms: X 910279; HMR-279; FK-779
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model .
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Cat. No.: HY-P992453
Synonyms: MTBT1466A; RG-6315
RO-7303509 (MTBT1466A; RG-6315) is a human monoclonal antibody and TGFβ3 neutralizer. RO-7303509 targets the profibrotic mediator TGFβ3 to alleviate fibrosis. RO-7303509 can be administered via subcutaneous or intravenous routes and is used in research on systemic sclerosis . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P991959

Target:  

CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma.
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