48

48 Publications Verification

Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3

Category:

Microorganisms Monophenols Ketones, Aldehydes, Acids Disease markers Endocrine diseases Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

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48

Liothyronine sodium

48 Publications Verification

Cat. No.: HY-A0070

CAS No.: 55-06-1

Synonyms: Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium

Category:

Monophenols Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

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48

Liothyronine sodium hydrate

48 Publications Verification

Cat. No.: HY-A0070B

CAS No.: 345957-19-9

Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate

Category:

Monophenols Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

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25

Resmetirom

25 Cited Publications

Cat. No.: HY-12216

CAS No.: 920509-32-6

Purity: 99.90%

Synonyms: MGL-3196; VIA-3196

Target:

Thyroid Hormone Receptor

Research Areas:

Cardiovascular Disease Endocrinology

Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .

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16

KT5823

16 Cited Publications

Cat. No.: HY-N6791

CAS No.: 126643-37-6

Target:

PKA PKC Bacterial Apoptosis Antibiotic

Research Areas:

Infection Inflammation/Immunology

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

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15

L-Thyroxine

15 Cited Publications

Cat. No.: HY-18341

CAS No.: 51-48-9

Synonyms: Levothyroxine; T4

Category:

Endocrine diseases Endogenous metabolite Immune System Disorder Monophenols Ketones, Aldehydes, Acids Disease markers Phenols Nervous System Disorder Disease Research Fields Endocrinology

Target:

Thyroid Hormone Receptor Endogenous Metabolite

L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

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14

L-Thyroxine sodium

14 Cited Publications

Cat. No.: HY-18341B

CAS No.: 55-03-8

Synonyms: Levothyroxine sodium; T4 sodium

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Thyroid Hormone Receptor Endogenous Metabolite

L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

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14

L-Thyroxine sodium salt pentahydrate

14 Cited Publications

Cat. No.: HY-18341A

CAS No.: 6106-07-6

Synonyms: Sodium levothyroxine pentahydrate

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Thyroid Hormone Receptor Endogenous Metabolite

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

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7

Sobetirome

7 Cited Publications

Cat. No.: HY-14823

CAS No.: 211110-63-3

Purity: 99.85%

Synonyms: GC-1; QRX-431

Target:

Thyroid Hormone Receptor

Research Areas:

Metabolic Disease Endocrinology

Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC₅₀ of 0.16 μM .

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5

NH-3

5 Cited Publications

Cat. No.: HY-141513

CAS No.: 447415-26-1

Purity: 99.41%

Target:

Thyroid Hormone Receptor

Research Areas:

Neurological Disease

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC₅₀ of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment . NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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5

Thyroxine sulfate

5 Cited Publications

Cat. No.: HY-101406

CAS No.: 77074-49-8

Purity: 99.84%

Synonyms: T4 Sulfate

Category:

Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology

Target:

Thyroid Hormone Receptor Drug Metabolite Endogenous Metabolite

Thyroxine sulfate is a thyroid hormone metabolite.

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5

TR antagonist 1

5 Cited Publications

Cat. No.: HY-111443

CAS No.: 500794-88-7

Purity: 99.57%

Target:

Thyroid Hormone Receptor

Research Areas:

Metabolic Disease Endocrinology

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC₅₀s of 36 and 22 nM for TRα and TRβ, respectively.

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4

Methimazole

4 Cited Publications

Cat. No.: HY-B0208

CAS No.: 60-56-0

Synonyms: Thiamazole

Target:

Thyroid Hormone Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity .

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4

Protirelin

4 Cited Publications

Cat. No.: HY-P0002

CAS No.: 24305-27-9

Synonyms: Thyrotropin-releasing-hormone; TRH

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Thyroid Hormone Receptor Endogenous Metabolite

Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

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