352

352 Publications Verification

Target:

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .

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165

JSH-23

165 Cited Publications

Cat. No.: HY-13982

CAS No.: 749886-87-1

Purity: 99.30%

Target:

NF-κB

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

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126

CH-223191

126 Cited Publications

Cat. No.: HY-12684

CAS No.: 301326-22-7

Purity: 99.96%

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Cancer

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

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119

GSK-872

119 Cited Publications

Cat. No.: HY-101872

CAS No.: 1346546-69-7

Purity: 99.80%

Target:

RIP kinase

Research Areas:

Inflammation/Immunology

GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

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119

GSK-872 hydrochloride

119 Cited Publications

Cat. No.: HY-101872A

CAS No.: 2703752-81-0

Purity: 99.21%

Target:

RIP kinase

Research Areas:

Inflammation/Immunology

GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

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82

Neomycin sulfate

82 Cited Publications

Cat. No.: HY-B0470

CAS No.: 1405-10-3

Category:

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

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72

IWR-1

72 Cited Publications

Cat. No.: HY-12238

CAS No.: 1127442-82-3

Purity: 99.60%

Synonyms: endo-IWR 1; IWR-1-endo

Target:

Organoid Wnt

Research Areas:

Inflammation/Immunology Cancer

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

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68

Poly (I:C):Kanamycin (1:1) sodium

68 Cited Publications

Cat. No.: HY-135748A

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:

Infection Cancer

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

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60

Fatostatin

60 Cited Publications

Cat. No.: HY-14452

CAS No.: 125256-00-0

Purity: 99.85%

Synonyms: 125B11

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

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60

Fatostatin hydrobromide

60 Cited Publications

Cat. No.: HY-14452A

CAS No.: 298197-04-3

Purity: 99.52%

Synonyms: 125B11 hydrobromide

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .

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45

SN50

45 Cited Publications

Cat. No.: HY-P0151

CAS No.: 213546-53-3

Target:

NF-κB

Research Areas:

Inflammation/Immunology

SN50 is a cell permeable inhibitor of NF-κB translocation.

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36

(-)-DHMEQ

36 Cited Publications

Cat. No.: HY-14645

CAS No.: 287194-40-5

Purity: 99.37%

Synonyms: Dehydroxymethylepoxyquinomicin

Target:

NF-κB

Research Areas:

Inflammation/Immunology Cancer

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity .

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